TY - JOUR
T1 - Biologically relevant small radicals
AU - Bauer, Georg
AU - Chatgilialoglu, Chryssostomos
AU - Gebicki, Jerzy L.
AU - Gebicka, Lidia
AU - Gescheidt, Georg
AU - Golding, Bernard T.
AU - Goldstein, Sara
AU - Kaizer, Jozsef
AU - Merenyi, Gabor
AU - Speien, Gabor
AU - Wardman, Peter
PY - 2008
Y1 - 2008
N2 - Biologically relevant small radicals are at the focus of the working group 4 (WG4) of the COST Action CM0603 (Free Radicals in Chemical Biology, CHEMBIORADICAL). This article surveys the areas of research being undertaken by the partners in WG4. The character of the radicals is described together with experimental techniques utilized to follow their structure and reactivity. Specifically, C-, S-, N- and O-centered radicals of small size, and their interaction with different biomolecules are described. Processes at the molecular level exemplifying important biological signaling and damaging pathways are introduced.
AB - Biologically relevant small radicals are at the focus of the working group 4 (WG4) of the COST Action CM0603 (Free Radicals in Chemical Biology, CHEMBIORADICAL). This article surveys the areas of research being undertaken by the partners in WG4. The character of the radicals is described together with experimental techniques utilized to follow their structure and reactivity. Specifically, C-, S-, N- and O-centered radicals of small size, and their interaction with different biomolecules are described. Processes at the molecular level exemplifying important biological signaling and damaging pathways are introduced.
KW - Antioxidants
KW - Reactive carbon species
KW - Reactive nitrogen species
KW - Reactive oxygen species
KW - Reactive sulfur species
KW - Signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=54049111441&partnerID=8YFLogxK
U2 - 10.2533/chimia.2008.704
DO - 10.2533/chimia.2008.704
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AN - SCOPUS:54049111441
SN - 0009-4293
VL - 62
SP - 704
EP - 712
JO - Chimia
JF - Chimia
IS - 9
ER -