Biologically relevant small radicals

Georg Bauer; Chryssostomos Chatgilialoglu; Jerzy L. Gebicki; Lidia Gebicka; Georg Gescheidt; Bernard T. Golding; Sara Goldstein; Jozsef Kaizer; Gabor Merenyi; Gabor Speien; Peter Wardman

doi:10.2533/chimia.2008.704

Biologically relevant small radicals

Georg Bauer
, Chryssostomos Chatgilialoglu
, Jerzy L. Gebicki
, Lidia Gebicka
, Georg Gescheidt
, Bernard T. Golding
, Sara Goldstein^*
, Jozsef Kaizer
, Gabor Merenyi
, Gabor Speien
, Peter Wardman

^*Corresponding author for this work

School of Nursing

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Biologically relevant small radicals are at the focus of the working group 4 (WG4) of the COST Action CM0603 (Free Radicals in Chemical Biology, CHEMBIORADICAL). This article surveys the areas of research being undertaken by the partners in WG4. The character of the radicals is described together with experimental techniques utilized to follow their structure and reactivity. Specifically, C-, S-, N- and O-centered radicals of small size, and their interaction with different biomolecules are described. Processes at the molecular level exemplifying important biological signaling and damaging pathways are introduced.

Original language	English
Pages (from-to)	704-712
Number of pages	9
Journal	Chimia
Volume	62
Issue number	9
DOIs	https://doi.org/10.2533/chimia.2008.704
State	Published - 2008

Keywords

Antioxidants
Reactive carbon species
Reactive nitrogen species
Reactive oxygen species
Reactive sulfur species
Signaling pathways

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10.2533/chimia.2008.704

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keywords = "Antioxidants, Reactive carbon species, Reactive nitrogen species, Reactive oxygen species, Reactive sulfur species, Signaling pathways",

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AU - Bauer, Georg

AU - Chatgilialoglu, Chryssostomos

AU - Gebicki, Jerzy L.

AU - Gebicka, Lidia

AU - Gescheidt, Georg

AU - Golding, Bernard T.

AU - Goldstein, Sara

AU - Kaizer, Jozsef

AU - Merenyi, Gabor

AU - Speien, Gabor

AU - Wardman, Peter

PY - 2008

Y1 - 2008

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AB - Biologically relevant small radicals are at the focus of the working group 4 (WG4) of the COST Action CM0603 (Free Radicals in Chemical Biology, CHEMBIORADICAL). This article surveys the areas of research being undertaken by the partners in WG4. The character of the radicals is described together with experimental techniques utilized to follow their structure and reactivity. Specifically, C-, S-, N- and O-centered radicals of small size, and their interaction with different biomolecules are described. Processes at the molecular level exemplifying important biological signaling and damaging pathways are introduced.

KW - Antioxidants

KW - Reactive carbon species

KW - Reactive nitrogen species

KW - Reactive oxygen species

KW - Reactive sulfur species

KW - Signaling pathways

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Biologically relevant small radicals

Abstract

Keywords

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