Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Dean D. Metcalfe*, Ruby Pawankar, Steven J. Ackerman, Cem Akin, Frederic Clayton, Franco H. Falcone, Gerald J. Gleich, Anne Marie Irani, Mats W. Johansson, Amy D. Klion, Kristin M. Leiferman, Francesca Levi-Schaffer, Gunnar Nilsson, Yoshimichi Okayama, Calman Prussin, John T. Schroeder, Lawrence B. Schwartz, Hans Uwe Simon, Andrew F. Walls, Massimo Triggiani

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations


Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.

Original languageAmerican English
Article number7
JournalWorld Allergy Organization Journal
Issue number1
StatePublished - 2016

Bibliographical note

Funding Information:
The authors would like to acknowledge the members of the World Allergy Organization's Committee on Eosinophils, Mast Cells, and Basophils in Allergic Disease, 2012-2013 and 2013-2014. DDM are ADK are supported by the Division of Intramural Research of NIAID/NIH. SJA is supported in part by research grants from the FDA (R01FD004086), NIH (R21HL118588), American Partnership for Eosinophilic Disorders (APFED), and University of Illinois, Chicago. MWJ is mainly supported by research grants from the NIH (P01 HL088594 and 1U10 HL109168 [PI: N. N. Jarjour]).

Publisher Copyright:
© 2016 Metcalfe et al.


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