Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Dean D. Metcalfe; Ruby Pawankar; Steven J. Ackerman; Cem Akin; Frederic Clayton; Franco H. Falcone; Gerald J. Gleich; Anne Marie Irani; Mats W. Johansson; Amy D. Klion; Kristin M. Leiferman; Francesca Levi-Schaffer; Gunnar Nilsson; Yoshimichi Okayama; Calman Prussin; John T. Schroeder; Lawrence B. Schwartz; Hans Uwe Simon; Andrew F. Walls; Massimo Triggiani

doi:10.1186/s40413-016-0094-3

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Dean D. Metcalfe^*, Ruby Pawankar, Steven J. Ackerman, Cem Akin, Frederic Clayton, Franco H. Falcone, Gerald J. Gleich, Anne Marie Irani, Mats W. Johansson, Amy D. Klion, Kristin M. Leiferman, Francesca Levi-Schaffer, Gunnar Nilsson, Yoshimichi Okayama, Calman Prussin, John T. Schroeder, Lawrence B. Schwartz, Hans Uwe Simon, Andrew F. Walls, Massimo Triggiani

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

109 Scopus citations

Abstract

Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.

Original language	American English
Article number	7
Journal	World Allergy Organization Journal
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s40413-016-0094-3
State	Published - 2016

Bibliographical note

Funding Information:
The authors would like to acknowledge the members of the World Allergy Organization's Committee on Eosinophils, Mast Cells, and Basophils in Allergic Disease, 2012-2013 and 2013-2014. DDM are ADK are supported by the Division of Intramural Research of NIAID/NIH. SJA is supported in part by research grants from the FDA (R01FD004086), NIH (R21HL118588), American Partnership for Eosinophilic Disorders (APFED), and University of Illinois, Chicago. MWJ is mainly supported by research grants from the NIH (P01 HL088594 and 1U10 HL109168 [PI: N. N. Jarjour]).

Publisher Copyright:
© 2016 Metcalfe et al.

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Metcalfe, D. D., Pawankar, R., Ackerman, S. J., Akin, C., Clayton, F., Falcone, F. H., Gleich, G. J., Irani, A. M., Johansson, M. W., Klion, A. D., Leiferman, K. M., Levi-Schaffer, F., Nilsson, G., Okayama, Y., Prussin, C., Schroeder, J. T., Schwartz, L. B., Simon, H. U., Walls, A. F., & Triggiani, M. (2016). Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases. World Allergy Organization Journal, 9(1), Article 7. https://doi.org/10.1186/s40413-016-0094-3

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title = "Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases",

abstract = "Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.",

author = "Metcalfe, {Dean D.} and Ruby Pawankar and Ackerman, {Steven J.} and Cem Akin and Frederic Clayton and Falcone, {Franco H.} and Gleich, {Gerald J.} and Irani, {Anne Marie} and Johansson, {Mats W.} and Klion, {Amy D.} and Leiferman, {Kristin M.} and Francesca Levi-Schaffer and Gunnar Nilsson and Yoshimichi Okayama and Calman Prussin and Schroeder, {John T.} and Schwartz, {Lawrence B.} and Simon, {Hans Uwe} and Walls, {Andrew F.} and Massimo Triggiani",

note = "Funding Information: The authors would like to acknowledge the members of the World Allergy Organization's Committee on Eosinophils, Mast Cells, and Basophils in Allergic Disease, 2012-2013 and 2013-2014. DDM are ADK are supported by the Division of Intramural Research of NIAID/NIH. SJA is supported in part by research grants from the FDA (R01FD004086), NIH (R21HL118588), American Partnership for Eosinophilic Disorders (APFED), and University of Illinois, Chicago. MWJ is mainly supported by research grants from the NIH (P01 HL088594 and 1U10 HL109168 [PI: N. N. Jarjour]). Publisher Copyright: {\textcopyright} 2016 Metcalfe et al.",

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doi = "10.1186/s40413-016-0094-3",

language = "American English",

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journal = "World Allergy Organization Journal",

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Metcalfe, DD, Pawankar, R, Ackerman, SJ, Akin, C, Clayton, F, Falcone, FH, Gleich, GJ, Irani, AM, Johansson, MW, Klion, AD, Leiferman, KM, Levi-Schaffer, F, Nilsson, G, Okayama, Y, Prussin, C, Schroeder, JT, Schwartz, LB, Simon, HU, Walls, AF & Triggiani, M 2016, 'Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases', World Allergy Organization Journal, vol. 9, no. 1, 7. https://doi.org/10.1186/s40413-016-0094-3

TY - JOUR

T1 - Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

AU - Metcalfe, Dean D.

AU - Pawankar, Ruby

AU - Ackerman, Steven J.

AU - Akin, Cem

AU - Clayton, Frederic

AU - Falcone, Franco H.

AU - Gleich, Gerald J.

AU - Irani, Anne Marie

AU - Johansson, Mats W.

AU - Klion, Amy D.

AU - Leiferman, Kristin M.

AU - Levi-Schaffer, Francesca

AU - Nilsson, Gunnar

AU - Okayama, Yoshimichi

AU - Prussin, Calman

AU - Schroeder, John T.

AU - Schwartz, Lawrence B.

AU - Simon, Hans Uwe

AU - Walls, Andrew F.

AU - Triggiani, Massimo

N1 - Funding Information: The authors would like to acknowledge the members of the World Allergy Organization's Committee on Eosinophils, Mast Cells, and Basophils in Allergic Disease, 2012-2013 and 2013-2014. DDM are ADK are supported by the Division of Intramural Research of NIAID/NIH. SJA is supported in part by research grants from the FDA (R01FD004086), NIH (R21HL118588), American Partnership for Eosinophilic Disorders (APFED), and University of Illinois, Chicago. MWJ is mainly supported by research grants from the NIH (P01 HL088594 and 1U10 HL109168 [PI: N. N. Jarjour]). Publisher Copyright: © 2016 Metcalfe et al.

PY - 2016

Y1 - 2016

N2 - Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.

AB - Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.

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U2 - 10.1186/s40413-016-0094-3

DO - 10.1186/s40413-016-0094-3

M3 - Review article

AN - SCOPUS:85027929499

SN - 1939-4551

VL - 9

JO - World Allergy Organization Journal

JF - World Allergy Organization Journal

IS - 1

M1 - 7

ER -

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

Abstract

Bibliographical note

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