TY - JOUR
T1 - Birth gap and the recurrence risk of autism spectrum disorders
T2 - A population-based cohort study
AU - Beenstock, Michael
AU - Raz, Raanan
AU - Levine, Hagai
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/7/4
Y1 - 2015/7/4
N2 - Population-based data on the magnitude and determinants of Autism Spectrum Disorder (ASD) recurrence risk in families with an index case are rare. We examined whether short birth gaps and other birth spacing factors increase the risk of recurrence, using a population-based cohort study in Israel. We examined records of younger siblings of index cases (children diagnosed with ASD), and estimated recurrence risk and its determinants. Overall, 5.25% (261/4976) of younger siblings were diagnosed with ASD. Younger siblings with birth gaps less than two years of their index case had significantly higher risk compared to the rest (odds ratio = 1.66, 95% CI 1.25-2.22). The association remained significant in models adjusted for sex of the index cases and their younger siblings, ethnicity, parental ages and birth order (odds ratio = 1.43, CI 1.03-1.96). This finding suggests that short birth gaps from the index case increase the risk of ASD among younger siblings.
AB - Population-based data on the magnitude and determinants of Autism Spectrum Disorder (ASD) recurrence risk in families with an index case are rare. We examined whether short birth gaps and other birth spacing factors increase the risk of recurrence, using a population-based cohort study in Israel. We examined records of younger siblings of index cases (children diagnosed with ASD), and estimated recurrence risk and its determinants. Overall, 5.25% (261/4976) of younger siblings were diagnosed with ASD. Younger siblings with birth gaps less than two years of their index case had significantly higher risk compared to the rest (odds ratio = 1.66, 95% CI 1.25-2.22). The association remained significant in models adjusted for sex of the index cases and their younger siblings, ethnicity, parental ages and birth order (odds ratio = 1.43, CI 1.03-1.96). This finding suggests that short birth gaps from the index case increase the risk of ASD among younger siblings.
KW - Autism spectrum disorder recurrence risk
KW - Birth gap
KW - Birth order
KW - Birth spacing
KW - Epidemiology
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=84947276714&partnerID=8YFLogxK
U2 - 10.1016/j.rasd.2015.06.001
DO - 10.1016/j.rasd.2015.06.001
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AN - SCOPUS:84947276714
SN - 1750-9467
VL - 17
SP - 86
EP - 94
JO - Research in Autism Spectrum Disorders
JF - Research in Autism Spectrum Disorders
ER -