TY - JOUR
T1 - Blood volume regulation in dehydrated rodents
T2 - Plasma protein turnover and sedimentation coefficients
AU - Horowitz, M.
AU - Borut, A.
PY - 1975/8/1
Y1 - 1975/8/1
N2 - 1. 1. Plasma albumin and globulin turnover, their sedimentation coefficients (S20) and total plasma protein were measured in dehydrated spiny mice (Acomys cahirinus) and laboratory rats. 2. 2. Due to dehydration the incorporation of 14C-1-leucine into plasma proteins increased. The half-lives of the labelled fractions decreased by the same proportion and no change was found in S20. Total plasma protein concentration increased. This is true for both species. 3. 3. The role of changes in plasma protein turnover vs changes in blood capillary permeability in relation to plasma protein and blood volume regulation in dehydrated rodents is discussed.
AB - 1. 1. Plasma albumin and globulin turnover, their sedimentation coefficients (S20) and total plasma protein were measured in dehydrated spiny mice (Acomys cahirinus) and laboratory rats. 2. 2. Due to dehydration the incorporation of 14C-1-leucine into plasma proteins increased. The half-lives of the labelled fractions decreased by the same proportion and no change was found in S20. Total plasma protein concentration increased. This is true for both species. 3. 3. The role of changes in plasma protein turnover vs changes in blood capillary permeability in relation to plasma protein and blood volume regulation in dehydrated rodents is discussed.
KW - Acomys cahirinus
KW - dehydration
KW - desert rodents
KW - exchange of albumin with extravascular albumin pool
KW - plasma proteins concentration
KW - Plasma proteins turnover
KW - Rattus norvegicus
KW - sedimentation coefficients
UR - http://www.scopus.com/inward/record.url?scp=0016541483&partnerID=8YFLogxK
U2 - 10.1016/0300-9629(75)90062-6
DO - 10.1016/0300-9629(75)90062-6
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C2 - 237706
AN - SCOPUS:0016541483
SN - 0300-9629
VL - 51
SP - 827
EP - 831
JO - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
JF - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
IS - 4
ER -