Blood volume regulation in dehydrated rodents: Plasma protein turnover and sedimentation coefficients

M. Horowitz*, A. Borut

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

1. 1. Plasma albumin and globulin turnover, their sedimentation coefficients (S20) and total plasma protein were measured in dehydrated spiny mice (Acomys cahirinus) and laboratory rats. 2. 2. Due to dehydration the incorporation of 14C-1-leucine into plasma proteins increased. The half-lives of the labelled fractions decreased by the same proportion and no change was found in S20. Total plasma protein concentration increased. This is true for both species. 3. 3. The role of changes in plasma protein turnover vs changes in blood capillary permeability in relation to plasma protein and blood volume regulation in dehydrated rodents is discussed.

Original languageEnglish
Pages (from-to)827-831
Number of pages5
JournalComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
Volume51
Issue number4
DOIs
StatePublished - 1 Aug 1975

Keywords

  • Acomys cahirinus
  • dehydration
  • desert rodents
  • exchange of albumin with extravascular albumin pool
  • plasma proteins concentration
  • Plasma proteins turnover
  • Rattus norvegicus
  • sedimentation coefficients

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