Blood volume regulation in dehydrated rodents: Plasma protein turnover and sedimentation coefficients

M. Horowitz; A. Borut

doi:10.1016/0300-9629(75)90062-6

Blood volume regulation in dehydrated rodents: Plasma protein turnover and sedimentation coefficients

M. Horowitz^*
, A. Borut

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

1. 1. Plasma albumin and globulin turnover, their sedimentation coefficients (S₂₀) and total plasma protein were measured in dehydrated spiny mice (Acomys cahirinus) and laboratory rats. 2. 2. Due to dehydration the incorporation of ¹⁴C-1-leucine into plasma proteins increased. The half-lives of the labelled fractions decreased by the same proportion and no change was found in S₂₀. Total plasma protein concentration increased. This is true for both species. 3. 3. The role of changes in plasma protein turnover vs changes in blood capillary permeability in relation to plasma protein and blood volume regulation in dehydrated rodents is discussed.

Original language	English
Pages (from-to)	827-831
Number of pages	5
Journal	Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/0300-9629(75)90062-6
State	Published - 1 Aug 1975

Keywords

Acomys cahirinus
Plasma proteins turnover
Rattus norvegicus
dehydration
desert rodents
exchange of albumin with extravascular albumin pool
plasma proteins concentration
sedimentation coefficients

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10.1016/0300-9629(75)90062-6

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title = "Blood volume regulation in dehydrated rodents: Plasma protein turnover and sedimentation coefficients",

abstract = "1. 1. Plasma albumin and globulin turnover, their sedimentation coefficients (S20) and total plasma protein were measured in dehydrated spiny mice (Acomys cahirinus) and laboratory rats. 2. 2. Due to dehydration the incorporation of 14C-1-leucine into plasma proteins increased. The half-lives of the labelled fractions decreased by the same proportion and no change was found in S20. Total plasma protein concentration increased. This is true for both species. 3. 3. The role of changes in plasma protein turnover vs changes in blood capillary permeability in relation to plasma protein and blood volume regulation in dehydrated rodents is discussed.",

keywords = "Acomys cahirinus, Plasma proteins turnover, Rattus norvegicus, dehydration, desert rodents, exchange of albumin with extravascular albumin pool, plasma proteins concentration, sedimentation coefficients",

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AU - Borut, A.

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AB - 1. 1. Plasma albumin and globulin turnover, their sedimentation coefficients (S20) and total plasma protein were measured in dehydrated spiny mice (Acomys cahirinus) and laboratory rats. 2. 2. Due to dehydration the incorporation of 14C-1-leucine into plasma proteins increased. The half-lives of the labelled fractions decreased by the same proportion and no change was found in S20. Total plasma protein concentration increased. This is true for both species. 3. 3. The role of changes in plasma protein turnover vs changes in blood capillary permeability in relation to plasma protein and blood volume regulation in dehydrated rodents is discussed.

KW - Acomys cahirinus

KW - Plasma proteins turnover

KW - Rattus norvegicus

KW - dehydration

KW - desert rodents

KW - exchange of albumin with extravascular albumin pool

KW - plasma proteins concentration

KW - sedimentation coefficients

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JO - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

JF - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

IS - 4

ER -

Blood volume regulation in dehydrated rodents: Plasma protein turnover and sedimentation coefficients

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