Bone marrow transplantation for severe aplastic anemia in HLA identical siblings using total lymphoid irradiation (TLI) and cyclophosphamide: Transplantation Proceedings

S. Slavin; E. Naprastek; Z. Weshler; Dina Steiner-Salz

Bone marrow transplantation for severe aplastic anemia in HLA identical siblings using total lymphoid irradiation (TLI) and cyclophosphamide: Transplantation Proceedings

S. Slavin, E. Naprastek, Z. Weshler, Dina Steiner-Salz

Faculty of Medicine

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13 Scopus citations

Abstract

Our pilot study suggests that the combination of fractionated TLI and CY is well tolerated by pancytopenic patients and permits rapid marrow engraftment. Whether TLI reduces the incidence and/or the severity of GVHD in bone marrow transplantation in man cannot be determined on the basis of the limited experience described here. Nevertheless, the results have produced sufficient enthusiasm for further clinical trials in nonmalignant hematologic disorders.

Original language	English
Pages (from-to)	668-670
Number of pages	3
Journal	Transplantation Proceedings
Volume	15
Issue number	1
State	Published - 1983

Bibliographical note

Export Date: 03 October 2022; Cited By: 13; CODEN: TRPPA

Keywords

cyclophosphamide
HLA antigen
methotrexate
aplastic anemia
blood and hemopoietic system
bone marrow transplantation
case report
drug therapy
human
immunosuppressive treatment
intravenous drug administration
lymph node irradiation
lymphatic system
sibling
therapy

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Slavin, S., Naprastek, E., Weshler, Z., & Steiner-Salz , D. (1983). Bone marrow transplantation for severe aplastic anemia in HLA identical siblings using total lymphoid irradiation (TLI) and cyclophosphamide: Transplantation Proceedings. Transplantation Proceedings, 15(1), 668-670. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020957909&partnerID=40&md5=8f5e2b104681619f7200b43132541811

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abstract = "Our pilot study suggests that the combination of fractionated TLI and CY is well tolerated by pancytopenic patients and permits rapid marrow engraftment. Whether TLI reduces the incidence and/or the severity of GVHD in bone marrow transplantation in man cannot be determined on the basis of the limited experience described here. Nevertheless, the results have produced sufficient enthusiasm for further clinical trials in nonmalignant hematologic disorders.",

keywords = "cyclophosphamide, HLA antigen, methotrexate, aplastic anemia, blood and hemopoietic system, bone marrow transplantation, case report, drug therapy, human, immunosuppressive treatment, intravenous drug administration, lymph node irradiation, lymphatic system, sibling, therapy",

author = "S. Slavin and E. Naprastek and Z. Weshler and Dina Steiner-Salz",

note = "Export Date: 03 October 2022; Cited By: 13; CODEN: TRPPA",

year = "1983",

language = "אנגלית",

volume = "15",

pages = "668--670",

journal = "Transplantation Proceedings",

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Slavin, S, Naprastek, E, Weshler, Z & Steiner-Salz , D 1983, 'Bone marrow transplantation for severe aplastic anemia in HLA identical siblings using total lymphoid irradiation (TLI) and cyclophosphamide: Transplantation Proceedings', Transplantation Proceedings, vol. 15, no. 1, pp. 668-670. <https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020957909&partnerID=40&md5=8f5e2b104681619f7200b43132541811>

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T2 - Transplantation Proceedings

AU - Slavin, S.

AU - Naprastek, E.

AU - Weshler, Z.

AU - Steiner-Salz , Dina

N1 - Export Date: 03 October 2022; Cited By: 13; CODEN: TRPPA

PY - 1983

Y1 - 1983

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AB - Our pilot study suggests that the combination of fractionated TLI and CY is well tolerated by pancytopenic patients and permits rapid marrow engraftment. Whether TLI reduces the incidence and/or the severity of GVHD in bone marrow transplantation in man cannot be determined on the basis of the limited experience described here. Nevertheless, the results have produced sufficient enthusiasm for further clinical trials in nonmalignant hematologic disorders.

KW - cyclophosphamide

KW - HLA antigen

KW - methotrexate

KW - aplastic anemia

KW - blood and hemopoietic system

KW - bone marrow transplantation

KW - case report

KW - drug therapy

KW - human

KW - immunosuppressive treatment

KW - intravenous drug administration

KW - lymph node irradiation

KW - lymphatic system

KW - sibling

KW - therapy

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SN - 0041-1345

VL - 15

SP - 668

EP - 670

JO - Transplantation Proceedings

JF - Transplantation Proceedings

IS - 1

ER -

Bone marrow transplantation for severe aplastic anemia in HLA identical siblings using total lymphoid irradiation (TLI) and cyclophosphamide: Transplantation Proceedings

Abstract

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