Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake

Hao Jiang, Danielle St. Ulme, Geneva Dickens, Alia Chabuk, Miriam Lavarreda, Philip Lazarovici, Gordon Guroff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Human p140(trk) and p75(NGFR) were transfected separately into 3T3 cells. Nerve growth factor stimulates calcium uptake into both transfectants but not into untransfected 3T3 cells. p140(trk) cells were stimulated maximally by 25 ng/ml; 100 ng/ml was submaximal for p75(NGFR) cells. K-252a inhibits the effect of NGF on p140(trk) cells but not on p75(NGFR) cells; brain-derived neurotrophic factor stimulates calcium uptake in p75(NGFR) cells but not in p140(trk) cells. The data suggest that both nerve growth factor receptors could be involved in the nerve growth factor-mediated actions of calcium on its target cells: neuronal survival, neuronal protection, and synaptic plasticity.

Original languageEnglish
Pages (from-to)6835-6837
Number of pages3
JournalJournal of Biological Chemistry
Volume272
Issue number11
DOIs
StatePublished - 14 Mar 1997

Fingerprint

Dive into the research topics of 'Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake'. Together they form a unique fingerprint.

Cite this