Brain circuits for pain and its treatment

Nicole Mercer Lindsay; Chong Chen; Gadi Gilam; Sean Mackey; Grégory Scherrer

doi:10.1126/scitranslmed.abj7360

Brain circuits for pain and its treatment

Nicole Mercer Lindsay, Chong Chen, Gadi Gilam, Sean Mackey^*, Grégory Scherrer^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

90 Scopus citations

Abstract

Pain is a multidimensional experience with sensory-discriminative, affective-motivational, and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering for patients with chronic pain, motivating research and drug development efforts to investigate and modulate neural activity in the brain’s circuits encoding pain unpleasantness. Here, we review progress in understanding the organization of emotion, motivation, cognition, and descending modulation circuits for pain perception. We describe the molecularly defined neuron types that collectively shape pain multidimensionality and its aversive quality. We also review how pharmacological, stimulation, neurofeedback, surgical, and cognitive-behavioral interventions alter activity in these circuits to relieve chronic pain.

Original language	English
Article number	eabj7360
Journal	Science Translational Medicine
Volume	13
Issue number	619
DOIs	https://doi.org/10.1126/scitranslmed.abj7360
State	Published - 10 Nov 2021
Externally published	Yes

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© 2021 The Authors, some rights reserved;

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Brain circuits for pain and its treatment

Abstract

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