Brain injury-dependent expression of activity-dependent neuroprotective protein

Roy Zaltzman; Alexander Alexandrovich; Sara M. Beni; Victoria Trembovler; Esther Shohami; Illana Gozes

doi:10.1385/JMN:24:2:181

Brain injury-dependent expression of activity-dependent neuroprotective protein

Roy Zaltzman, Alexander Alexandrovich, Sara M. Beni, Victoria Trembovler, Esther Shohami, Illana Gozes^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Activity-dependent neuroprotective protein (ADNP), a crucial brain development factor, contains a unique sequence, termed NAPVSIPQ, which protects mice against closed head injury (CHI). The aim of this study was to determine whether CHI affects ADNP mRNA expression in the injured brain hemisphere. Male C57JBL/6J mice were subjected to CHI. Brains were removed 5 h, 24 h, 7 d, and 29 d post-CHI. A comparison was made between ADNP mRNA in the injured versus the noninjured hemisphere using real-time polymerase chain reaction. A nonsignificant change (p > 0.05) was found 5 h, 24 h, and 7 d post-CHI. However, a significant increase (p < 0.05) in ADNP mRNA expression was detected in the injured cerebral hemisphere 29 d post-CHI. The data presented may be associated with ADNP's crucial involvement in brain development and response to injury.

Original language	English
Pages (from-to)	181-187
Number of pages	7
Journal	Journal of Molecular Neuroscience
Volume	24
Issue number	2
DOIs	https://doi.org/10.1385/JMN:24:2:181
State	Published - Sep 2004

Keywords

Activity-dependent neuroprotective protein (ADNP)
Gene expression
Head trauma
Real-time polymerase chain reaction (PCR)

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10.1385/JMN:24:2:181

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title = "Brain injury-dependent expression of activity-dependent neuroprotective protein",

abstract = "Activity-dependent neuroprotective protein (ADNP), a crucial brain development factor, contains a unique sequence, termed NAPVSIPQ, which protects mice against closed head injury (CHI). The aim of this study was to determine whether CHI affects ADNP mRNA expression in the injured brain hemisphere. Male C57JBL/6J mice were subjected to CHI. Brains were removed 5 h, 24 h, 7 d, and 29 d post-CHI. A comparison was made between ADNP mRNA in the injured versus the noninjured hemisphere using real-time polymerase chain reaction. A nonsignificant change (p > 0.05) was found 5 h, 24 h, and 7 d post-CHI. However, a significant increase (p < 0.05) in ADNP mRNA expression was detected in the injured cerebral hemisphere 29 d post-CHI. The data presented may be associated with ADNP's crucial involvement in brain development and response to injury.",

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AU - Trembovler, Victoria

AU - Shohami, Esther

AU - Gozes, Illana

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Brain injury-dependent expression of activity-dependent neuroprotective protein

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Keywords

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