Brain Organization and Human Diseases

Tamar Sapir*, Dalit Sela-Donenfeld, Maayan Karlinski, Orly Reiner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


The cortex is a highly organized structure that develops from the caudal regions of the segmented neural tube. Its spatial organization sets the stage for future functional arealization. Here, we suggest using a developmental perspective to describe and understand the etiology of common cortical malformations and their manifestation in the human brain.

Original languageAmerican English
Article number1642
Issue number10
StatePublished - 1 May 2022

Bibliographical note

Funding Information:
Funding: This research was funded by research grants from the William and Joan Brodsky Foundation and the Edward F. Anixter Family Foundation, the Helen and Martin Kimmel Institute for Stem Cell Research, the Nella and Leon Benoziyo Center for Neurological Diseases, the David and Fela Shapell Family Center for Genetic Disorders Research, the Brenden-Mann Women’s Innovation Impact Fund, The Irving B. Harris Fund for New Directions in Brain Research, the Irving Bieber, M.D. and Toby Bieber, M.D. Memorial Research Fund, The Leff Family, Barbara & Roberto Kaminitz, Sergio & Sônia Lozinsky, Debbie Koren, Jack and Lenore Lowenthal, and the Dears Foundation, a research grant from the Weizmann SABRA—Yeda-Sela—WRC Program, the Estate of Emile Mimran, and The Maurice and Vivienne Wohl Biology Endowment Canadian Institutes of Health Research (CIHR), the International Development Research Centre (IDRC), the Israel Science Foundation (ISF) and the Azrieli Foundation (2397/18), United States-Israel Binational Science Foundation (BSF; Grant No. 2017006).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • cortical development
  • forebrain
  • holoprosencephaly
  • lissencephaly
  • neuronal migration
  • signaling factors
  • telencephalon


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