Brain Organization and Human Diseases

Tamar Sapir*, Dalit Sela-Donenfeld, Maayan Karlinski, Orly Reiner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


The cortex is a highly organized structure that develops from the caudal regions of the segmented neural tube. Its spatial organization sets the stage for future functional arealization. Here, we suggest using a developmental perspective to describe and understand the etiology of common cortical malformations and their manifestation in the human brain.

Original languageAmerican English
Article number1642
Issue number10
StatePublished - 1 May 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • cortical development
  • forebrain
  • holoprosencephaly
  • lissencephaly
  • neuronal migration
  • signaling factors
  • telencephalon


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