Breaking and making of the nuclear envelope

Ayelet Margalit, Sylvia Vlcek, Yosef Gruenbaum*, Roland Foisner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

During mitosis, a single nucleus gives rise to two nuclei that are identical to the parent nucleus. Mitosis consists of a continuous sequence of events that must be carried out once and only once. Two such important events are the disassembly of the nuclear envelope (NE) during the first stages of mitosis, and its accurate reassembly during the last stages of mitosis. NE breakdown (NEBD) is initiated when maturation-promoting factor (MPF) enters the nucleus and starts phosphorylating nuclear pore complexes (NPCs) and nuclear lamina proteins, followed by NPC and lamina breakdown. Nuclear reassembly starts when nuclear membranes assemble onto the chromatin. This article focuses on the different models of NEBD and reassembly with emphasis on recent data.

Original languageEnglish
Pages (from-to)454-465
Number of pages12
JournalJournal of Cellular Biochemistry
Volume95
Issue number3
DOIs
StatePublished - 1 Jun 2005

Keywords

  • Cell cycle
  • Mitosis
  • Nuclear assembly
  • Nuclear lamina
  • Nuclear membrane
  • Nuclear pore complexes

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