TY - JOUR
T1 - Broader distribution of plasmid-mediated quinolone resistance in the United States
AU - Robicsek, A.
AU - Sahm, D. F.
AU - Strahilevitz, J.
AU - Jacoby, G. A.
AU - Hooper, D. C.
PY - 2005/7
Y1 - 2005/7
N2 - The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.
AB - The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.
UR - http://www.scopus.com/inward/record.url?scp=21444457103&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.7.3001-3003.2005
DO - 10.1128/AAC.49.7.3001-3003.2005
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C2 - 15980384
AN - SCOPUS:21444457103
SN - 0066-4804
VL - 49
SP - 3001
EP - 3003
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 7
ER -
