Broader distribution of plasmid-mediated quinolone resistance in the United States

A. Robicsek, D. F. Sahm, J. Strahilevitz, G. A. Jacoby, D. C. Hooper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.

Original languageAmerican English
Pages (from-to)3001-3003
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number7
StatePublished - Jul 2005
Externally publishedYes


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