Broader distribution of plasmid-mediated quinolone resistance in the United States

A. Robicsek; D. F. Sahm; J. Strahilevitz; G. A. Jacoby; D. C. Hooper

doi:10.1128/AAC.49.7.3001-3003.2005

Broader distribution of plasmid-mediated quinolone resistance in the United States

A. Robicsek
, D. F. Sahm
, J. Strahilevitz
, G. A. Jacoby
, D. C. Hooper^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.

Original language	English
Pages (from-to)	3001-3003
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	7
DOIs	https://doi.org/10.1128/AAC.49.7.3001-3003.2005
State	Published - Jul 2005
Externally published	Yes

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10.1128/AAC.49.7.3001-3003.2005

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title = "Broader distribution of plasmid-mediated quinolone resistance in the United States",

abstract = "The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10\%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17\%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.",

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AU - Sahm, D. F.

AU - Strahilevitz, J.

AU - Jacoby, G. A.

AU - Hooper, D. C.

PY - 2005/7

Y1 - 2005/7

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AB - The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.

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IS - 7

ER -

Broader distribution of plasmid-mediated quinolone resistance in the United States

Abstract

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