Building blocks for the synthesis of post-translationally modified glycated peptides and proteins

Stefano Carganico; Paolo Rovero; Jose A. Halperin; Anna Maria Papini; Michael Chorev

doi:10.1002/psc.1105

Building blocks for the synthesis of post-translationally modified glycated peptides and proteins

Stefano Carganico, Paolo Rovero, Jose A. Halperin, Anna Maria Papini, Michael Chorev^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Growing interest in synthetic peptides carrying post-traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of Na-Fmoc-Lys-OH derivatives containing Ne-1-deoxyfructopyranosyl moiety.

Original language	English
Pages (from-to)	67-71
Number of pages	5
Journal	Journal of Peptide Science
Volume	15
Issue number	2
DOIs	https://doi.org/10.1002/psc.1105
State	Published - 2009
Externally published	Yes

Keywords

Amadori rearrangement
Amadori-containing building block
Glycation
Lys(N-1-deoxyfructopyranosyl)
SPPS
Site-specific modification

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10.1002/psc.1105

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title = "Building blocks for the synthesis of post-translationally modified glycated peptides and proteins",

abstract = "Growing interest in synthetic peptides carrying post-traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of Na-Fmoc-Lys-OH derivatives containing Ne-1-deoxyfructopyranosyl moiety.",

keywords = "Amadori rearrangement, Amadori-containing building block, Glycation, Lys(N-1-deoxyfructopyranosyl), SPPS, Site-specific modification",

author = "Stefano Carganico and Paolo Rovero and Halperin, \{Jose A.\} and Papini, \{Anna Maria\} and Michael Chorev",

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AU - Carganico, Stefano

AU - Rovero, Paolo

AU - Halperin, Jose A.

AU - Papini, Anna Maria

AU - Chorev, Michael

PY - 2009

Y1 - 2009

N2 - Growing interest in synthetic peptides carrying post-traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of Na-Fmoc-Lys-OH derivatives containing Ne-1-deoxyfructopyranosyl moiety.

AB - Growing interest in synthetic peptides carrying post-traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of Na-Fmoc-Lys-OH derivatives containing Ne-1-deoxyfructopyranosyl moiety.

KW - Amadori rearrangement

KW - Amadori-containing building block

KW - Glycation

KW - Lys(N-1-deoxyfructopyranosyl)

KW - SPPS

KW - Site-specific modification

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IS - 2

ER -

Building blocks for the synthesis of post-translationally modified glycated peptides and proteins

Abstract

Keywords

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