Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: A multinational point prevalence study of hospitalised patients

Marcos I. Restrepo; Bettina L. Babu; Luis F. Reyes; James D. Chalmers; Nilam J. Soni; Oriol Sibila; Paola Faverio; Catia Cilloniz; William Rodriguez-Cintron; Stefano Aliberti; P. K. Aruj; S. Attorri; E. Barimboim; J. P. Caeiro; M. I. Garzón; V. H. Cambursano; A. Ceccato; J. Chertcoff; F. Lascar; F. Di Tulio; A. C. Díaz; L. de Vedia; M. C. Ganaha; S. Lambert; G. Lopardo; C. M. Luna; A. G. Malberti; N. Morcillo; S. Tartara; C. Pensotti; B. Pereyra; P. G. Scapellato; J. P. Stagnaro; S. Shah; F. Lötsch; F. Thalhammer; K. Anseeuw; C. A. Francois; E. Van Braeckel; J. L. Vincent; M. Z. Djimon; J. Bashi; R. Dodo; S. A. Nouér; P. Chipev; M. Encheva; D. Miteva; D. Petkova; A. Dodo Balkissou; E. W. Pefura Yone; B. H. Mbatchou Ngahane; N. Shen; J. F. Xu; C. A. Bustamante Rico; R. Buitrago; F. J. Pereira Paternina; J. M. Kayembe Ntumba; V. V. Carevic; M. Jakopovic; M. Jankovic; Z. Matkovic; I. Mitrecic; M. L. Bouchy Jacobsson; A. Bro Christensen; U. C. Heitmann Bødtger; C. Niels Meyer; A. Vestergaard Jensen; G. Baunbæk-Knudsen; P. T. Petersen; S. Andersen; I. E. Abd El-Wahhab; N. Elsayed Morsy; H. Shafiek; E. Sobh; K. Abdella Abdulsemed; F. Bertrand; C. Brun-Buisson; E. de Montmollin; M. Fartoukh; J. Messika; P. Tattevin; A. Khoury; B. Ebruke; M. Dreher; M. Kolditz; M. Meisinger; M. W. Pletz; S. Hagel; J. Rupp; T. Schaberg; M. Spielmanns; P. Creutz; N. Suttorp; B. Siaw-Lartey; K. Dimakou; D. Papapetrou; E. Tsigou; D. Ampazis; E. Kaimakamis; M. Bhatia; R. Dhar; G. D'Souza; R. Garg; P. A. Koul; P. A. Mahesh; B. S. Jayaraj; K. V. Narayan; H. B. Udnur; S. B. Krishnamurthy; S. Kant; R. Swarnakar; S. Limaye; S. Salvi; K. Golshani; V. M. Keatings; I. Martin-Loeches; Y. Maor; J. Strahilevitz; S. Battaglia; M. Carrabba; P. Ceriana; M. Confalonieri; A. D. Monforte; B. Del Prato; M. De Rosa; R. Fantini; G. Fiorentino; M. A. Gammino; F. Menzella; G. Milani; S. Nava; G. Palmiero; R. Petrino; B. Gabrielli; P. Rossi; C. Sorino; G. Steinhilber; A. Zanforlin; F. Franzetti; M. Carugati; M. Morosi; E. Monge; M. Carone; V. Patella; S. Scarlata; A. Comel; K. Kurahashi; Z. A. Bacha; D. B. Ugalde; O. C. Zuñiga; J. F. Villegas; M. Medenica; E. M.W. van de Garde; D. Raj Mihsra; P. Shrestha; E. Ridgeon; B. I. Awokola; O. N.O. Nwankwo; A. B. Olufunlola; S. Olumide; K. N. Ukwaja; M. Irfan; L. Minarowski; S. Szymon; F. Froes; P. Leuschner; M. Meireles; C. Ferrão; J. Neves; S. B. Ravara; V. Brocovschii; C. Ion; D. Rusu; C. Toma; D. Chirita; C. M. Dorobat; A. Birkun; A. Kaluzhenina; A. Almotairi; Z. A. Ali Bukhary; J. Edathodu; A. Fathy; A. M. Abdulaziz Enani; N. E. Mohamed; J. U. Memon; A. Bella; N. Bogdanović; B. Milenkovic; D. Pesut; C. Feldman; H. K. Yum; L. Borderìas; N. M. Bordon Garcia; H. Cabello Alarcón; A. Torres; V. Diaz-Brito; X. Casas; A. E. González; M. L. Fernández-Almira; M. Gallego; I. Gaspar-García; J. G. Del Castillo; P. J. Victoria; E. L. Martínez; R. M. de Molina; P. J. Marcos; R. Menéndez; A. Pando-Sandoval; C. P. Aymerich; A. L. de la Torre; I. García-Olivé; J. Rello; S. Moyano; F. Sanz; A. Rodrigo-Troyano; J. Solé-Violán; A. Uranga; J. F.M. van Boven; E. V. Torra; J. A. Pujol; A. A. Fiogbe; F. Yangui; S. Bilaceroglu; L. Dalar; U. Yilmaz; A. Bogomolov; N. Elahi; D. J. Dhasmana; A. Feneley; R. Ions; J. Skeemer; G. Woltmann; C. Hancock; A. T. Hill; B. Rudran; S. Ruiz-Buitrago; M. Campbell; P. Whitaker; A. Youzguin; A. Singanayagam; K. S. Allen; V. Brito; J. Dietz; C. E. Dysart; S. M. Kellie; C. J. Zablocki; R. G. MurphyMurphy; R. A. Franco-Sadud; G. Meier; M. Gaga; T. L. Holland; S. P. Bergin; F. Kheir; M. Landmeier; M. Lois; G. B. Nair; H. Patel; S. Saito; J. Noda; C. I. Hinojosa; S. M. Levine; L. F. Angel; A. Anzueto; K. S. Whitlow; J. Hipskind; K. Sukhija; V. Totten; R. G. Wunderink; R. D. Shah; K. J. Mateyo; L. Noriega; E. Alvarado; M. Aman; L. Labra

doi:10.1183/13993003.01190-2017

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: A multinational point prevalence study of hospitalised patients

Marcos I. Restrepo^*, Bettina L. Babu, Luis F. Reyes, James D. Chalmers, Nilam J. Soni, Oriol Sibila, Paola Faverio, Catia Cilloniz, William Rodriguez-Cintron, Stefano Aliberti, P. K. Aruj, S. Attorri, E. Barimboim, J. P. Caeiro, M. I. Garzón, V. H. Cambursano, A. Ceccato, J. Chertcoff, F. Lascar, F. Di TulioA. C. Díaz, L. de Vedia, M. C. Ganaha, S. Lambert, G. Lopardo, C. M. Luna, A. G. Malberti, N. Morcillo, S. Tartara, C. Pensotti, B. Pereyra, P. G. Scapellato, J. P. Stagnaro, S. Shah, F. Lötsch, F. Thalhammer, K. Anseeuw, C. A. Francois, E. Van Braeckel, J. L. Vincent, M. Z. Djimon, J. Bashi, R. Dodo, S. A. Nouér, P. Chipev, M. Encheva, D. Miteva, D. Petkova, A. Dodo Balkissou, E. W. Pefura Yone, B. H. Mbatchou Ngahane, N. Shen, J. F. Xu, C. A. Bustamante Rico, R. Buitrago, F. J. Pereira Paternina, J. M. Kayembe Ntumba, V. V. Carevic, M. Jakopovic, M. Jankovic, Z. Matkovic, I. Mitrecic, M. L. Bouchy Jacobsson, A. Bro Christensen, U. C. Heitmann Bødtger, C. Niels Meyer, A. Vestergaard Jensen, G. Baunbæk-Knudsen, P. T. Petersen, S. Andersen, I. E. Abd El-Wahhab, N. Elsayed Morsy, H. Shafiek, E. Sobh, K. Abdella Abdulsemed, F. Bertrand, C. Brun-Buisson, E. de Montmollin, M. Fartoukh, J. Messika, P. Tattevin, A. Khoury, B. Ebruke, M. Dreher, M. Kolditz, M. Meisinger, M. W. Pletz, S. Hagel, J. Rupp, T. Schaberg, M. Spielmanns, P. Creutz, N. Suttorp, B. Siaw-Lartey, K. Dimakou, D. Papapetrou, E. Tsigou, D. Ampazis, E. Kaimakamis, M. Bhatia, R. Dhar, G. D'Souza, R. Garg, P. A. Koul, P. A. Mahesh, B. S. Jayaraj, K. V. Narayan, H. B. Udnur, S. B. Krishnamurthy, S. Kant, R. Swarnakar, S. Limaye, S. Salvi, K. Golshani, V. M. Keatings, I. Martin-Loeches, Y. Maor, J. Strahilevitz, S. Battaglia, M. Carrabba, P. Ceriana, M. Confalonieri, A. D. Monforte, B. Del Prato, M. De Rosa, R. Fantini, G. Fiorentino, M. A. Gammino, F. Menzella, G. Milani, S. Nava, G. Palmiero, R. Petrino, B. Gabrielli, P. Rossi, C. Sorino, G. Steinhilber, A. Zanforlin, F. Franzetti, M. Carugati, M. Morosi, E. Monge, M. Carone, V. Patella, S. Scarlata, A. Comel, K. Kurahashi, Z. A. Bacha, D. B. Ugalde, O. C. Zuñiga, J. F. Villegas, M. Medenica, E. M.W. van de Garde, D. Raj Mihsra, P. Shrestha, E. Ridgeon, B. I. Awokola, O. N.O. Nwankwo, A. B. Olufunlola, S. Olumide, K. N. Ukwaja, M. Irfan, L. Minarowski, S. Szymon, F. Froes, P. Leuschner, M. Meireles, C. Ferrão, J. Neves, S. B. Ravara, V. Brocovschii, C. Ion, D. Rusu, C. Toma, D. Chirita, C. M. Dorobat, A. Birkun, A. Kaluzhenina, A. Almotairi, Z. A. Ali Bukhary, J. Edathodu, A. Fathy, A. M. Abdulaziz Enani, N. E. Mohamed, J. U. Memon, A. Bella, N. Bogdanović, B. Milenkovic, D. Pesut, C. Feldman, H. K. Yum, L. Borderìas, N. M. Bordon Garcia, H. Cabello Alarcón, A. Torres, V. Diaz-Brito, X. Casas, A. E. González, M. L. Fernández-Almira, M. Gallego, I. Gaspar-García, J. G. Del Castillo, P. J. Victoria, E. L. Martínez, R. M. de Molina, P. J. Marcos, R. Menéndez, A. Pando-Sandoval, C. P. Aymerich, A. L. de la Torre, I. García-Olivé, J. Rello, S. Moyano, F. Sanz, A. Rodrigo-Troyano, J. Solé-Violán, A. Uranga, J. F.M. van Boven, E. V. Torra, J. A. Pujol, A. A. Fiogbe, F. Yangui, S. Bilaceroglu, L. Dalar, U. Yilmaz, A. Bogomolov, N. Elahi, D. J. Dhasmana, A. Feneley, R. Ions, J. Skeemer, G. Woltmann, C. Hancock, A. T. Hill, B. Rudran, S. Ruiz-Buitrago, M. Campbell, P. Whitaker, A. Youzguin, A. Singanayagam, K. S. Allen, V. Brito, J. Dietz, C. E. Dysart, S. M. Kellie, C. J. Zablocki, R. G. MurphyMurphy, R. A. Franco-Sadud, G. Meier, M. Gaga, T. L. Holland, S. P. Bergin, F. Kheir, M. Landmeier, M. Lois, G. B. Nair, H. Patel, S. Saito, J. Noda, C. I. Hinojosa, S. M. Levine, L. F. Angel, A. Anzueto, K. S. Whitlow, J. Hipskind, K. Sukhija, V. Totten, R. G. Wunderink, R. D. Shah, K. J. Mateyo, L. Noriega, E. Alvarado, M. Aman, L. Labra

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients.

Original language	American English
Article number	1701190
Journal	European Respiratory Journal
Volume	52
Issue number	2
DOIs	https://doi.org/10.1183/13993003.01190-2017
State	Published - 1 Aug 2018

Bibliographical note

Funding Information:
Acknowledgements: We would like to thank the European Respiratory Society, the World Federation of Societies of Intensive and Critical Care Medicine, the American College of Chest Physicians, the Asociación Latinoamericana de Tórax and the Sociedad Argentina de Infectología for their support of this project.

Funding Information:
Support statement: This project was unfunded. However, Nilam Soni’s time is partially funded by the Department of Veterans Affairs, Quality Enhancement Research Initiative (QUERI) Partnered Evaluation Initiative Grant (HX002263-01A1). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans Affairs, nor the United States Government.

Publisher Copyright:
© ERS 2018.

Access to Document

10.1183/13993003.01190-2017

Cite this

Restrepo, M. I., Babu, B. L., Reyes, L. F., Chalmers, J. D., Soni, N. J., Sibila, O., Faverio, P., Cilloniz, C., Rodriguez-Cintron, W., Aliberti, S., Aruj, P. K., Attorri, S., Barimboim, E., Caeiro, J. P., Garzón, M. I., Cambursano, V. H., Ceccato, A., Chertcoff, J., Lascar, F., ... Labra, L. (2018). Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: A multinational point prevalence study of hospitalised patients. European Respiratory Journal, 52(2), Article 1701190. https://doi.org/10.1183/13993003.01190-2017

@article{efac616a4d1643ff93dfad26d285b253,

title = "Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: A multinational point prevalence study of hospitalised patients",

abstract = "Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients.",

author = "Restrepo, {Marcos I.} and Babu, {Bettina L.} and Reyes, {Luis F.} and Chalmers, {James D.} and Soni, {Nilam J.} and Oriol Sibila and Paola Faverio and Catia Cilloniz and William Rodriguez-Cintron and Stefano Aliberti and Aruj, {P. K.} and S. Attorri and E. Barimboim and Caeiro, {J. P.} and Garz{\'o}n, {M. I.} and Cambursano, {V. H.} and A. Ceccato and J. Chertcoff and F. Lascar and {Di Tulio}, F. and D{\'i}az, {A. C.} and {de Vedia}, L. and Ganaha, {M. C.} and S. Lambert and G. Lopardo and Luna, {C. M.} and Malberti, {A. G.} and N. Morcillo and S. Tartara and C. Pensotti and B. Pereyra and Scapellato, {P. G.} and Stagnaro, {J. P.} and S. Shah and F. L{\"o}tsch and F. Thalhammer and K. Anseeuw and Francois, {C. A.} and {Van Braeckel}, E. and Vincent, {J. L.} and Djimon, {M. Z.} and J. Bashi and R. Dodo and Nou{\'e}r, {S. A.} and P. Chipev and M. Encheva and D. Miteva and D. Petkova and {Dodo Balkissou}, A. and {Pefura Yone}, {E. W.} and {Mbatchou Ngahane}, {B. H.} and N. Shen and Xu, {J. F.} and {Bustamante Rico}, {C. A.} and R. Buitrago and {Pereira Paternina}, {F. J.} and {Kayembe Ntumba}, {J. M.} and Carevic, {V. V.} and M. Jakopovic and M. Jankovic and Z. Matkovic and I. Mitrecic and {Bouchy Jacobsson}, {M. L.} and {Bro Christensen}, A. and {Heitmann B{\o}dtger}, {U. C.} and {Niels Meyer}, C. and {Vestergaard Jensen}, A. and G. Baunb{\ae}k-Knudsen and Petersen, {P. T.} and S. Andersen and {Abd El-Wahhab}, {I. E.} and {Elsayed Morsy}, N. and H. Shafiek and E. Sobh and {Abdella Abdulsemed}, K. and F. Bertrand and C. Brun-Buisson and {de Montmollin}, E. and M. Fartoukh and J. Messika and P. Tattevin and A. Khoury and B. Ebruke and M. Dreher and M. Kolditz and M. Meisinger and Pletz, {M. W.} and S. Hagel and J. Rupp and T. Schaberg and M. Spielmanns and P. Creutz and N. Suttorp and B. Siaw-Lartey and K. Dimakou and D. Papapetrou and E. Tsigou and D. Ampazis and E. Kaimakamis and M. Bhatia and R. Dhar and G. D'Souza and R. Garg and Koul, {P. A.} and Mahesh, {P. A.} and Jayaraj, {B. S.} and Narayan, {K. V.} and Udnur, {H. B.} and Krishnamurthy, {S. B.} and S. Kant and R. Swarnakar and S. Limaye and S. Salvi and K. Golshani and Keatings, {V. M.} and I. Martin-Loeches and Y. Maor and J. Strahilevitz and S. Battaglia and M. Carrabba and P. Ceriana and M. Confalonieri and Monforte, {A. D.} and {Del Prato}, B. and {De Rosa}, M. and R. Fantini and G. Fiorentino and Gammino, {M. A.} and F. Menzella and G. Milani and S. Nava and G. Palmiero and R. Petrino and B. Gabrielli and P. Rossi and C. Sorino and G. Steinhilber and A. Zanforlin and F. Franzetti and M. Carugati and M. Morosi and E. Monge and M. Carone and V. Patella and S. Scarlata and A. Comel and K. Kurahashi and Bacha, {Z. A.} and Ugalde, {D. B.} and Zu{\~n}iga, {O. C.} and Villegas, {J. F.} and M. Medenica and {van de Garde}, {E. M.W.} and {Raj Mihsra}, D. and P. Shrestha and E. Ridgeon and Awokola, {B. I.} and Nwankwo, {O. N.O.} and Olufunlola, {A. B.} and S. Olumide and Ukwaja, {K. N.} and M. Irfan and L. Minarowski and S. Szymon and F. Froes and P. Leuschner and M. Meireles and C. Ferr{\~a}o and J. Neves and Ravara, {S. B.} and V. Brocovschii and C. Ion and D. Rusu and C. Toma and D. Chirita and Dorobat, {C. M.} and A. Birkun and A. Kaluzhenina and A. Almotairi and {Ali Bukhary}, {Z. A.} and J. Edathodu and A. Fathy and {Abdulaziz Enani}, {A. M.} and Mohamed, {N. E.} and Memon, {J. U.} and A. Bella and N. Bogdanovi{\'c} and B. Milenkovic and D. Pesut and C. Feldman and Yum, {H. K.} and L. Border{\`i}as and {Bordon Garcia}, {N. M.} and {Cabello Alarc{\'o}n}, H. and A. Torres and V. Diaz-Brito and X. Casas and Gonz{\'a}lez, {A. E.} and Fern{\'a}ndez-Almira, {M. L.} and M. Gallego and I. Gaspar-Garc{\'i}a and {Del Castillo}, {J. G.} and Victoria, {P. J.} and Mart{\'i}nez, {E. L.} and {de Molina}, {R. M.} and Marcos, {P. J.} and R. Men{\'e}ndez and A. Pando-Sandoval and Aymerich, {C. P.} and {de la Torre}, {A. L.} and I. Garc{\'i}a-Oliv{\'e} and J. Rello and S. Moyano and F. Sanz and A. Rodrigo-Troyano and J. Sol{\'e}-Viol{\'a}n and A. Uranga and {van Boven}, {J. F.M.} and Torra, {E. V.} and Pujol, {J. A.} and Fiogbe, {A. A.} and F. Yangui and S. Bilaceroglu and L. Dalar and U. Yilmaz and A. Bogomolov and N. Elahi and Dhasmana, {D. J.} and A. Feneley and R. Ions and J. Skeemer and G. Woltmann and C. Hancock and Hill, {A. T.} and B. Rudran and S. Ruiz-Buitrago and M. Campbell and P. Whitaker and A. Youzguin and A. Singanayagam and Allen, {K. S.} and V. Brito and J. Dietz and Dysart, {C. E.} and Kellie, {S. M.} and Zablocki, {C. J.} and MurphyMurphy, {R. G.} and Franco-Sadud, {R. A.} and G. Meier and M. Gaga and Holland, {T. L.} and Bergin, {S. P.} and F. Kheir and M. Landmeier and M. Lois and Nair, {G. B.} and H. Patel and S. Saito and J. Noda and Hinojosa, {C. I.} and Levine, {S. M.} and Angel, {L. F.} and A. Anzueto and Whitlow, {K. S.} and J. Hipskind and K. Sukhija and V. Totten and Wunderink, {R. G.} and Shah, {R. D.} and Mateyo, {K. J.} and L. Noriega and E. Alvarado and M. Aman and L. Labra",

note = "Funding Information: Acknowledgements: We would like to thank the European Respiratory Society, the World Federation of Societies of Intensive and Critical Care Medicine, the American College of Chest Physicians, the Asociaci{\'o}n Latinoamericana de T{\'o}rax and the Sociedad Argentina de Infectolog{\'i}a for their support of this project. Funding Information: Support statement: This project was unfunded. However, Nilam Soni{\textquoteright}s time is partially funded by the Department of Veterans Affairs, Quality Enhancement Research Initiative (QUERI) Partnered Evaluation Initiative Grant (HX002263-01A1). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans Affairs, nor the United States Government. Publisher Copyright: {\textcopyright} ERS 2018.",

year = "2018",

month = aug,

day = "1",

doi = "10.1183/13993003.01190-2017",

language = "American English",

volume = "52",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "2",

}

Restrepo, MI, Babu, BL, Reyes, LF, Chalmers, JD, Soni, NJ, Sibila, O, Faverio, P, Cilloniz, C, Rodriguez-Cintron, W, Aliberti, S, Aruj, PK, Attorri, S, Barimboim, E, Caeiro, JP, Garzón, MI, Cambursano, VH, Ceccato, A, Chertcoff, J, Lascar, F, Di Tulio, F, Díaz, AC, de Vedia, L, Ganaha, MC, Lambert, S, Lopardo, G, Luna, CM, Malberti, AG, Morcillo, N, Tartara, S, Pensotti, C, Pereyra, B, Scapellato, PG, Stagnaro, JP, Shah, S, Lötsch, F, Thalhammer, F, Anseeuw, K, Francois, CA, Van Braeckel, E, Vincent, JL, Djimon, MZ, Bashi, J, Dodo, R, Nouér, SA, Chipev, P, Encheva, M, Miteva, D, Petkova, D, Dodo Balkissou, A, Pefura Yone, EW, Mbatchou Ngahane, BH, Shen, N, Xu, JF, Bustamante Rico, CA, Buitrago, R, Pereira Paternina, FJ, Kayembe Ntumba, JM, Carevic, VV, Jakopovic, M, Jankovic, M, Matkovic, Z, Mitrecic, I, Bouchy Jacobsson, ML, Bro Christensen, A, Heitmann Bødtger, UC, Niels Meyer, C, Vestergaard Jensen, A, Baunbæk-Knudsen, G, Petersen, PT, Andersen, S, Abd El-Wahhab, IE, Elsayed Morsy, N, Shafiek, H, Sobh, E, Abdella Abdulsemed, K, Bertrand, F, Brun-Buisson, C, de Montmollin, E, Fartoukh, M, Messika, J, Tattevin, P, Khoury, A, Ebruke, B, Dreher, M, Kolditz, M, Meisinger, M, Pletz, MW, Hagel, S, Rupp, J, Schaberg, T, Spielmanns, M, Creutz, P, Suttorp, N, Siaw-Lartey, B, Dimakou, K, Papapetrou, D, Tsigou, E, Ampazis, D, Kaimakamis, E, Bhatia, M, Dhar, R, D'Souza, G, Garg, R, Koul, PA, Mahesh, PA, Jayaraj, BS, Narayan, KV, Udnur, HB, Krishnamurthy, SB, Kant, S, Swarnakar, R, Limaye, S, Salvi, S, Golshani, K, Keatings, VM, Martin-Loeches, I, Maor, Y, Strahilevitz, J, Battaglia, S, Carrabba, M, Ceriana, P, Confalonieri, M, Monforte, AD, Del Prato, B, De Rosa, M, Fantini, R, Fiorentino, G, Gammino, MA, Menzella, F, Milani, G, Nava, S, Palmiero, G, Petrino, R, Gabrielli, B, Rossi, P, Sorino, C, Steinhilber, G, Zanforlin, A, Franzetti, F, Carugati, M, Morosi, M, Monge, E, Carone, M, Patella, V, Scarlata, S, Comel, A, Kurahashi, K, Bacha, ZA, Ugalde, DB, Zuñiga, OC, Villegas, JF, Medenica, M, van de Garde, EMW, Raj Mihsra, D, Shrestha, P, Ridgeon, E, Awokola, BI, Nwankwo, ONO, Olufunlola, AB, Olumide, S, Ukwaja, KN, Irfan, M, Minarowski, L, Szymon, S, Froes, F, Leuschner, P, Meireles, M, Ferrão, C, Neves, J, Ravara, SB, Brocovschii, V, Ion, C, Rusu, D, Toma, C, Chirita, D, Dorobat, CM, Birkun, A, Kaluzhenina, A, Almotairi, A, Ali Bukhary, ZA, Edathodu, J, Fathy, A, Abdulaziz Enani, AM, Mohamed, NE, Memon, JU, Bella, A, Bogdanović, N, Milenkovic, B, Pesut, D, Feldman, C, Yum, HK, Borderìas, L, Bordon Garcia, NM, Cabello Alarcón, H, Torres, A, Diaz-Brito, V, Casas, X, González, AE, Fernández-Almira, ML, Gallego, M, Gaspar-García, I, Del Castillo, JG, Victoria, PJ, Martínez, EL, de Molina, RM, Marcos, PJ, Menéndez, R, Pando-Sandoval, A, Aymerich, CP, de la Torre, AL, García-Olivé, I, Rello, J, Moyano, S, Sanz, F, Rodrigo-Troyano, A, Solé-Violán, J, Uranga, A, van Boven, JFM, Torra, EV, Pujol, JA, Fiogbe, AA, Yangui, F, Bilaceroglu, S, Dalar, L, Yilmaz, U, Bogomolov, A, Elahi, N, Dhasmana, DJ, Feneley, A, Ions, R, Skeemer, J, Woltmann, G, Hancock, C, Hill, AT, Rudran, B, Ruiz-Buitrago, S, Campbell, M, Whitaker, P, Youzguin, A, Singanayagam, A, Allen, KS, Brito, V, Dietz, J, Dysart, CE, Kellie, SM, Zablocki, CJ, MurphyMurphy, RG, Franco-Sadud, RA, Meier, G, Gaga, M, Holland, TL, Bergin, SP, Kheir, F, Landmeier, M, Lois, M, Nair, GB, Patel, H, Saito, S, Noda, J, Hinojosa, CI, Levine, SM, Angel, LF, Anzueto, A, Whitlow, KS, Hipskind, J, Sukhija, K, Totten, V, Wunderink, RG, Shah, RD, Mateyo, KJ, Noriega, L, Alvarado, E, Aman, M & Labra, L 2018, 'Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: A multinational point prevalence study of hospitalised patients', European Respiratory Journal, vol. 52, no. 2, 1701190. https://doi.org/10.1183/13993003.01190-2017

TY - JOUR

T1 - Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia

T2 - A multinational point prevalence study of hospitalised patients

AU - Restrepo, Marcos I.

AU - Babu, Bettina L.

AU - Reyes, Luis F.

AU - Chalmers, James D.

AU - Soni, Nilam J.

AU - Sibila, Oriol

AU - Faverio, Paola

AU - Cilloniz, Catia

AU - Rodriguez-Cintron, William

AU - Aliberti, Stefano

AU - Aruj, P. K.

AU - Attorri, S.

AU - Barimboim, E.

AU - Caeiro, J. P.

AU - Garzón, M. I.

AU - Cambursano, V. H.

AU - Ceccato, A.

AU - Chertcoff, J.

AU - Lascar, F.

AU - Di Tulio, F.

AU - Díaz, A. C.

AU - de Vedia, L.

AU - Ganaha, M. C.

AU - Lambert, S.

AU - Lopardo, G.

AU - Luna, C. M.

AU - Malberti, A. G.

AU - Morcillo, N.

AU - Tartara, S.

AU - Pensotti, C.

AU - Pereyra, B.

AU - Scapellato, P. G.

AU - Stagnaro, J. P.

AU - Shah, S.

AU - Lötsch, F.

AU - Thalhammer, F.

AU - Anseeuw, K.

AU - Francois, C. A.

AU - Van Braeckel, E.

AU - Vincent, J. L.

AU - Djimon, M. Z.

AU - Bashi, J.

AU - Dodo, R.

AU - Nouér, S. A.

AU - Chipev, P.

AU - Encheva, M.

AU - Miteva, D.

AU - Petkova, D.

AU - Dodo Balkissou, A.

AU - Pefura Yone, E. W.

AU - Mbatchou Ngahane, B. H.

AU - Shen, N.

AU - Xu, J. F.

AU - Bustamante Rico, C. A.

AU - Buitrago, R.

AU - Pereira Paternina, F. J.

AU - Kayembe Ntumba, J. M.

AU - Carevic, V. V.

AU - Jakopovic, M.

AU - Jankovic, M.

AU - Matkovic, Z.

AU - Mitrecic, I.

AU - Bouchy Jacobsson, M. L.

AU - Bro Christensen, A.

AU - Heitmann Bødtger, U. C.

AU - Niels Meyer, C.

AU - Vestergaard Jensen, A.

AU - Baunbæk-Knudsen, G.

AU - Petersen, P. T.

AU - Andersen, S.

AU - Abd El-Wahhab, I. E.

AU - Elsayed Morsy, N.

AU - Shafiek, H.

AU - Sobh, E.

AU - Abdella Abdulsemed, K.

AU - Bertrand, F.

AU - Brun-Buisson, C.

AU - de Montmollin, E.

AU - Fartoukh, M.

AU - Messika, J.

AU - Tattevin, P.

AU - Khoury, A.

AU - Ebruke, B.

AU - Dreher, M.

AU - Kolditz, M.

AU - Meisinger, M.

AU - Pletz, M. W.

AU - Hagel, S.

AU - Rupp, J.

AU - Schaberg, T.

AU - Spielmanns, M.

AU - Creutz, P.

AU - Suttorp, N.

AU - Siaw-Lartey, B.

AU - Dimakou, K.

AU - Papapetrou, D.

AU - Tsigou, E.

AU - Ampazis, D.

AU - Kaimakamis, E.

AU - Bhatia, M.

AU - Dhar, R.

AU - D'Souza, G.

AU - Garg, R.

AU - Koul, P. A.

AU - Mahesh, P. A.

AU - Jayaraj, B. S.

AU - Narayan, K. V.

AU - Udnur, H. B.

AU - Krishnamurthy, S. B.

AU - Kant, S.

AU - Swarnakar, R.

AU - Limaye, S.

AU - Salvi, S.

AU - Golshani, K.

AU - Keatings, V. M.

AU - Martin-Loeches, I.

AU - Maor, Y.

AU - Strahilevitz, J.

AU - Battaglia, S.

AU - Carrabba, M.

AU - Ceriana, P.

AU - Confalonieri, M.

AU - Monforte, A. D.

AU - Del Prato, B.

AU - De Rosa, M.

AU - Fantini, R.

AU - Fiorentino, G.

AU - Gammino, M. A.

AU - Menzella, F.

AU - Milani, G.

AU - Nava, S.

AU - Palmiero, G.

AU - Petrino, R.

AU - Gabrielli, B.

AU - Rossi, P.

AU - Sorino, C.

AU - Steinhilber, G.

AU - Zanforlin, A.

AU - Franzetti, F.

AU - Carugati, M.

AU - Morosi, M.

AU - Monge, E.

AU - Carone, M.

AU - Patella, V.

AU - Scarlata, S.

AU - Comel, A.

AU - Kurahashi, K.

AU - Bacha, Z. A.

AU - Ugalde, D. B.

AU - Zuñiga, O. C.

AU - Villegas, J. F.

AU - Medenica, M.

AU - van de Garde, E. M.W.

AU - Raj Mihsra, D.

AU - Shrestha, P.

AU - Ridgeon, E.

AU - Awokola, B. I.

AU - Nwankwo, O. N.O.

AU - Olufunlola, A. B.

AU - Olumide, S.

AU - Ukwaja, K. N.

AU - Irfan, M.

AU - Minarowski, L.

AU - Szymon, S.

AU - Froes, F.

AU - Leuschner, P.

AU - Meireles, M.

AU - Ferrão, C.

AU - Neves, J.

AU - Ravara, S. B.

AU - Brocovschii, V.

AU - Ion, C.

AU - Rusu, D.

AU - Toma, C.

AU - Chirita, D.

AU - Dorobat, C. M.

AU - Birkun, A.

AU - Kaluzhenina, A.

AU - Almotairi, A.

AU - Ali Bukhary, Z. A.

AU - Edathodu, J.

AU - Fathy, A.

AU - Abdulaziz Enani, A. M.

AU - Mohamed, N. E.

AU - Memon, J. U.

AU - Bella, A.

AU - Bogdanović, N.

AU - Milenkovic, B.

AU - Pesut, D.

AU - Feldman, C.

AU - Yum, H. K.

AU - Borderìas, L.

AU - Bordon Garcia, N. M.

AU - Cabello Alarcón, H.

AU - Torres, A.

AU - Diaz-Brito, V.

AU - Casas, X.

AU - González, A. E.

AU - Fernández-Almira, M. L.

AU - Gallego, M.

AU - Gaspar-García, I.

AU - Del Castillo, J. G.

AU - Victoria, P. J.

AU - Martínez, E. L.

AU - de Molina, R. M.

AU - Marcos, P. J.

AU - Menéndez, R.

AU - Pando-Sandoval, A.

AU - Aymerich, C. P.

AU - de la Torre, A. L.

AU - García-Olivé, I.

AU - Rello, J.

AU - Moyano, S.

AU - Sanz, F.

AU - Rodrigo-Troyano, A.

AU - Solé-Violán, J.

AU - Uranga, A.

AU - van Boven, J. F.M.

AU - Torra, E. V.

AU - Pujol, J. A.

AU - Fiogbe, A. A.

AU - Yangui, F.

AU - Bilaceroglu, S.

AU - Dalar, L.

AU - Yilmaz, U.

AU - Bogomolov, A.

AU - Elahi, N.

AU - Dhasmana, D. J.

AU - Feneley, A.

AU - Ions, R.

AU - Skeemer, J.

AU - Woltmann, G.

AU - Hancock, C.

AU - Hill, A. T.

AU - Rudran, B.

AU - Ruiz-Buitrago, S.

AU - Campbell, M.

AU - Whitaker, P.

AU - Youzguin, A.

AU - Singanayagam, A.

AU - Allen, K. S.

AU - Brito, V.

AU - Dietz, J.

AU - Dysart, C. E.

AU - Kellie, S. M.

AU - Zablocki, C. J.

AU - MurphyMurphy, R. G.

AU - Franco-Sadud, R. A.

AU - Meier, G.

AU - Gaga, M.

AU - Holland, T. L.

AU - Bergin, S. P.

AU - Kheir, F.

AU - Landmeier, M.

AU - Lois, M.

AU - Nair, G. B.

AU - Patel, H.

AU - Saito, S.

AU - Noda, J.

AU - Hinojosa, C. I.

AU - Levine, S. M.

AU - Angel, L. F.

AU - Anzueto, A.

AU - Whitlow, K. S.

AU - Hipskind, J.

AU - Sukhija, K.

AU - Totten, V.

AU - Wunderink, R. G.

AU - Shah, R. D.

AU - Mateyo, K. J.

AU - Noriega, L.

AU - Alvarado, E.

AU - Aman, M.

AU - Labra, L.

N1 - Funding Information: Acknowledgements: We would like to thank the European Respiratory Society, the World Federation of Societies of Intensive and Critical Care Medicine, the American College of Chest Physicians, the Asociación Latinoamericana de Tórax and the Sociedad Argentina de Infectología for their support of this project. Funding Information: Support statement: This project was unfunded. However, Nilam Soni’s time is partially funded by the Department of Veterans Affairs, Quality Enhancement Research Initiative (QUERI) Partnered Evaluation Initiative Grant (HX002263-01A1). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans Affairs, nor the United States Government. Publisher Copyright: © ERS 2018.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients.

AB - Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients.

UR - http://www.scopus.com/inward/record.url?scp=85051459272&partnerID=8YFLogxK

U2 - 10.1183/13993003.01190-2017

DO - 10.1183/13993003.01190-2017

M3 - Article

C2 - 29976651

AN - SCOPUS:85051459272

SN - 0903-1936

VL - 52

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 2

M1 - 1701190

ER -

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: A multinational point prevalence study of hospitalised patients

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this