c-Fos as a regulator of degranulation and cytokine production in FcεRI-activated mast cells

Yu Nee Lee, Jan Tuckerman, Hovav Nechushtan, Gunter Schutz, Ehud Razin*, Peter Angel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

The AP-1 complex is composed of c-Jun and c-Fos and is a key component in the regulation of proinflammatory genes. Mast cells play a significant role in the initiation of many inflammatory responses, such as allergy and allergy-associated diseases. In the present work, we characterized the role of c-Fos in mast cell function by investigating IL-3-dependent cell proliferation, degranulation capability, and cytokine expression in c-Fos-deficient mice. In c-Fos-deficient mast cells, we found that FcεRI-mediated degranulation was significantly inhibited, which correlates with the reduced expression of SWAP-70, VAMP-7, and Synaptotagmin I genes, which are involved directly in the degranulation process. These findings show that c-Fos plays an important role in FcεRI-mediated regulation of mast cell function.

Original languageEnglish
Pages (from-to)2571-2577
Number of pages7
JournalJournal of Immunology
Volume173
Issue number4
DOIs
StatePublished - 15 Aug 2004

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