TY - JOUR
T1 - c-Fos as a regulator of degranulation and cytokine production in FcεRI-activated mast cells
AU - Lee, Yu Nee
AU - Tuckerman, Jan
AU - Nechushtan, Hovav
AU - Schutz, Gunter
AU - Razin, Ehud
AU - Angel, Peter
PY - 2004/8/15
Y1 - 2004/8/15
N2 - The AP-1 complex is composed of c-Jun and c-Fos and is a key component in the regulation of proinflammatory genes. Mast cells play a significant role in the initiation of many inflammatory responses, such as allergy and allergy-associated diseases. In the present work, we characterized the role of c-Fos in mast cell function by investigating IL-3-dependent cell proliferation, degranulation capability, and cytokine expression in c-Fos-deficient mice. In c-Fos-deficient mast cells, we found that FcεRI-mediated degranulation was significantly inhibited, which correlates with the reduced expression of SWAP-70, VAMP-7, and Synaptotagmin I genes, which are involved directly in the degranulation process. These findings show that c-Fos plays an important role in FcεRI-mediated regulation of mast cell function.
AB - The AP-1 complex is composed of c-Jun and c-Fos and is a key component in the regulation of proinflammatory genes. Mast cells play a significant role in the initiation of many inflammatory responses, such as allergy and allergy-associated diseases. In the present work, we characterized the role of c-Fos in mast cell function by investigating IL-3-dependent cell proliferation, degranulation capability, and cytokine expression in c-Fos-deficient mice. In c-Fos-deficient mast cells, we found that FcεRI-mediated degranulation was significantly inhibited, which correlates with the reduced expression of SWAP-70, VAMP-7, and Synaptotagmin I genes, which are involved directly in the degranulation process. These findings show that c-Fos plays an important role in FcεRI-mediated regulation of mast cell function.
UR - http://www.scopus.com/inward/record.url?scp=4043176237&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.173.4.2571
DO - 10.4049/jimmunol.173.4.2571
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C2 - 15294973
AN - SCOPUS:4043176237
SN - 0022-1767
VL - 173
SP - 2571
EP - 2577
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -