C-Me Bond Formation at All Methylene Bridges of the Calix[4]arene Scaffold

Ori Shalev, Silvio E. Biali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A reaction of a distal dibromo diketocalix[4]arene with excess MeLi, followed by acid-catalyzed dehydration, yields a derivative with a pair of opposite exocyclic double bonds, and a pair of trans methyl groups at the bridges. A reaction of a tetrabromo calix[4]arene derivative with excess MeLi yields a calix[4]arene derivative with all methylene bridges monomethylated in all-cis fashion.

Original languageAmerican English
Pages (from-to)3390-3393
Number of pages4
JournalOrganic Letters
Volume20
Issue number11
DOIs
StatePublished - 1 Jun 2018

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

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