TY - JOUR
T1 - C3-Activating proteases on human lymphoblastoid cells superinfected with epstein-barr virus
AU - Schulz, Thomas
AU - Dierich, Manfred P.
AU - Yefenof, Eitan
AU - Klein, George
PY - 1980/4
Y1 - 1980/4
N2 - Mouse spleen lymphocytes to which uncleaved human C3 had been attached were interacted with two EBV- lines (RAMOS and BJAB) and six EBV+ sublines (A.W-RAMOS, 11.W.A.RAMOS, EHR.A.RAMOS, EHR.B.RAMOS; GC-BJAB, BJAB/HRIK), which were obtained by superinfection of the EBV- lines with EBV. Depending on the presence of C3, the EBV- sublines except for EHR-A.RAMOS formed rosettes with the mouse spleen lymphocytes. The interaction was inhibitable by DFP. The experiments are interpreted as indicating the presence of proteolytic, C3-cleaving activity on the surface of the EBV+ sublines. The expression of this activity on the EBV+ lines only, correlates it to the transformation of EBV- lines into EBV+ lines.
AB - Mouse spleen lymphocytes to which uncleaved human C3 had been attached were interacted with two EBV- lines (RAMOS and BJAB) and six EBV+ sublines (A.W-RAMOS, 11.W.A.RAMOS, EHR.A.RAMOS, EHR.B.RAMOS; GC-BJAB, BJAB/HRIK), which were obtained by superinfection of the EBV- lines with EBV. Depending on the presence of C3, the EBV- sublines except for EHR-A.RAMOS formed rosettes with the mouse spleen lymphocytes. The interaction was inhibitable by DFP. The experiments are interpreted as indicating the presence of proteolytic, C3-cleaving activity on the surface of the EBV+ sublines. The expression of this activity on the EBV+ lines only, correlates it to the transformation of EBV- lines into EBV+ lines.
UR - http://www.scopus.com/inward/record.url?scp=0018854870&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(80)90246-4
DO - 10.1016/0008-8749(80)90246-4
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C2 - 6244899
AN - SCOPUS:0018854870
SN - 0008-8749
VL - 51
SP - 168
EP - 172
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -