C3-Activating proteases on human lymphoblastoid cells superinfected with epstein-barr virus

Thomas Schulz; Manfred P. Dierich; Eitan Yefenof; George Klein

doi:10.1016/0008-8749(80)90246-4

C3-Activating proteases on human lymphoblastoid cells superinfected with epstein-barr virus

Thomas Schulz
, Manfred P. Dierich^*
, Eitan Yefenof
, George Klein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Mouse spleen lymphocytes to which uncleaved human C3 had been attached were interacted with two EBV^- lines (RAMOS and BJAB) and six EBV⁺ sublines (A.W-RAMOS, 11.W.A.RAMOS, EHR.A.RAMOS, EHR.B.RAMOS; GC-BJAB, BJAB/HRIK), which were obtained by superinfection of the EBV^- lines with EBV. Depending on the presence of C3, the EBV^- sublines except for EHR-A.RAMOS formed rosettes with the mouse spleen lymphocytes. The interaction was inhibitable by DFP. The experiments are interpreted as indicating the presence of proteolytic, C3-cleaving activity on the surface of the EBV⁺ sublines. The expression of this activity on the EBV⁺ lines only, correlates it to the transformation of EBV^- lines into EBV⁺ lines.

Original language	English
Pages (from-to)	168-172
Number of pages	5
Journal	Cellular Immunology
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(80)90246-4
State	Published - Apr 1980
Externally published	Yes

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title = "C3-Activating proteases on human lymphoblastoid cells superinfected with epstein-barr virus",

abstract = "Mouse spleen lymphocytes to which uncleaved human C3 had been attached were interacted with two EBV- lines (RAMOS and BJAB) and six EBV+ sublines (A.W-RAMOS, 11.W.A.RAMOS, EHR.A.RAMOS, EHR.B.RAMOS; GC-BJAB, BJAB/HRIK), which were obtained by superinfection of the EBV- lines with EBV. Depending on the presence of C3, the EBV- sublines except for EHR-A.RAMOS formed rosettes with the mouse spleen lymphocytes. The interaction was inhibitable by DFP. The experiments are interpreted as indicating the presence of proteolytic, C3-cleaving activity on the surface of the EBV+ sublines. The expression of this activity on the EBV+ lines only, correlates it to the transformation of EBV- lines into EBV+ lines.",

author = "Thomas Schulz and Dierich, \{Manfred P.\} and Eitan Yefenof and George Klein",

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AU - Schulz, Thomas

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AU - Yefenof, Eitan

AU - Klein, George

PY - 1980/4

Y1 - 1980/4

N2 - Mouse spleen lymphocytes to which uncleaved human C3 had been attached were interacted with two EBV- lines (RAMOS and BJAB) and six EBV+ sublines (A.W-RAMOS, 11.W.A.RAMOS, EHR.A.RAMOS, EHR.B.RAMOS; GC-BJAB, BJAB/HRIK), which were obtained by superinfection of the EBV- lines with EBV. Depending on the presence of C3, the EBV- sublines except for EHR-A.RAMOS formed rosettes with the mouse spleen lymphocytes. The interaction was inhibitable by DFP. The experiments are interpreted as indicating the presence of proteolytic, C3-cleaving activity on the surface of the EBV+ sublines. The expression of this activity on the EBV+ lines only, correlates it to the transformation of EBV- lines into EBV+ lines.

AB - Mouse spleen lymphocytes to which uncleaved human C3 had been attached were interacted with two EBV- lines (RAMOS and BJAB) and six EBV+ sublines (A.W-RAMOS, 11.W.A.RAMOS, EHR.A.RAMOS, EHR.B.RAMOS; GC-BJAB, BJAB/HRIK), which were obtained by superinfection of the EBV- lines with EBV. Depending on the presence of C3, the EBV- sublines except for EHR-A.RAMOS formed rosettes with the mouse spleen lymphocytes. The interaction was inhibitable by DFP. The experiments are interpreted as indicating the presence of proteolytic, C3-cleaving activity on the surface of the EBV+ sublines. The expression of this activity on the EBV+ lines only, correlates it to the transformation of EBV- lines into EBV+ lines.

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C3-Activating proteases on human lymphoblastoid cells superinfected with epstein-barr virus

Abstract

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