TY - JOUR
T1 - Calcium-dependent activation and deactivation of rod outer segment phosphodiesterase is calmodulin-independent
AU - Del Priore, Lucian V.
AU - Lewis, Aaron
PY - 1983/5/31
Y1 - 1983/5/31
N2 - ATP-dependent activation and deactivation of retinal rod outer segment phosphodiesterase is affected by calcium [Kawamura, S. and Bownds, M. D., J. Gen. Physiol. 77:571-591(1981)]. Our data demonstrate that although calmodulin has been found in rod outer segments [Liu, Y. P. and Schwartz, H., Biochim. Biophys. Acta 526:186-193(1978); Kohnken, R. E. et al, J. Biol. Chem. 256:12517-12522(1981)], this protein is not involved in calcium-dependent phosphodiesterase activation at light levels at which calcium clearly affects this enzyme's activity. Furthermore, calmodulin does not mediate the calcium-dependent deactivation of phosphodiesterase.
AB - ATP-dependent activation and deactivation of retinal rod outer segment phosphodiesterase is affected by calcium [Kawamura, S. and Bownds, M. D., J. Gen. Physiol. 77:571-591(1981)]. Our data demonstrate that although calmodulin has been found in rod outer segments [Liu, Y. P. and Schwartz, H., Biochim. Biophys. Acta 526:186-193(1978); Kohnken, R. E. et al, J. Biol. Chem. 256:12517-12522(1981)], this protein is not involved in calcium-dependent phosphodiesterase activation at light levels at which calcium clearly affects this enzyme's activity. Furthermore, calmodulin does not mediate the calcium-dependent deactivation of phosphodiesterase.
UR - http://www.scopus.com/inward/record.url?scp=0021116460&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(83)90468-0
DO - 10.1016/0006-291X(83)90468-0
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C2 - 6305354
AN - SCOPUS:0021116460
SN - 0006-291X
VL - 113
SP - 317
EP - 324
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -