Calix[6]arenes incorporating functionalised substituents at the methylene bridges

Katerina Kogan, Norbert Itzhak, Silvio E. Biali

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The hexabromocalix[6]arene 5 reacts with p-tert-Bu-phenol, thymol and propargyl alcohol to afford the corresponding hexasubstituted methylene-functionalised calixarenes. The substituents at the bridges were further functionalised via acetylation or click chemistry. Reaction of the hexahydroxy derivative 10 with DAST afforded 11, a first example of a calixarene with all bridges monofluorinated.

Original languageAmerican English
Pages (from-to)704-709
Number of pages6
JournalSupramolecular Chemistry
Issue number11-12
StatePublished - Nov 2010

Bibliographical note

Funding Information:
This research was supported by the Israel Science Foundation (Grant No. 257/07).


  • calixarenes
  • methylene-functionalised
  • synthesis


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