Cancer cell–autonomous parainflammation mimics immune cell infiltration

Audrey Lasry, Dvir Aran, Atul J. Butte, Yinon Ben-Neriah*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Parainflammation is a unique variant of inflammation, char-discuss the implications of our findings in analyses of tumor acterized by epithelial-autonomous activation of inflammatory microenvironment, suggesting that as tumor cell gene expres-response. Parainflammation has been shown to strongly prosion may often mimic immune and inflammatory infiltration, mote mouse gut tumorigenesis upon p53 loss. In a recent study, caution should be applied when interpreting tumor expression we explored the prevalence of parainflammation in human data. We also address the connection between parainflamma-cancer and determined its relationship to certain molecular and tion and prevalence of p53 mutations in specific types of clinical parameters affecting treatment and prognosis. Parain-tumors, and cancer prevention by regular usage of NSAIDs. We flammation can be identified from a 40-gene signature and is suggest that parainflammation may serve as a novel biomarker found in both carcinoma cell lines and a variety of primary for screening patients who may particularly benefit from NSAID tumors, independently of tumor microenvironment. Here, we treatment.

Original languageAmerican English
Pages (from-to)3740-3744
Number of pages5
JournalCancer Research
Volume77
Issue number14
DOIs
StatePublished - 15 Jul 2017

Bibliographical note

Funding Information:
Relevant research in the laboratories of Y. Ben-Neriah and A.J. Butte was supported by grants from Israel Science Foundation (ISF)- Centers of Excellence, the European Research Council within the FP-7 (294390 PICHO), the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF), the Israel Cancer Research Fund, the NCI of the NIH (U24 CA195858), and the Gruss Lipper Family Foundation.

Publisher Copyright:
©2017 AACR.

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