TY - JOUR
T1 - Cancer dormancy
T2 - Isolation and characterization of dormant lymphoma cells
AU - Yefenof, Eitan
AU - Picker, Louis J.
AU - Scheuermann, Richard H.
AU - Tucker, Thomas F.
AU - Vitetta, Ellen S.
AU - Uhr, Jonathan W.
PY - 1993/3/1
Y1 - 1993/3/1
N2 - "Tumor dormancy" is an operational term used to describe a prolonged quiescent state in which tumor cells are present, but tumor progression is not clinically apparent. Although clinical examples of tumor dormancy abound, little is known regarding the mechanisms underlying this state. Here we utilize an antibody-induced dormancy model of an aggressive murine B-cell lymphoma (BCL1) and show that the induction of the dormant state is accompanied by dramatic changes in tumor cell morphology and cell cycle status. These data indicate the feasibility of altering the malignant phenotype of transformed cells by specific signals originating at the cell surface, and they suggest new opportunities for therapeutic intervention in cancer.
AB - "Tumor dormancy" is an operational term used to describe a prolonged quiescent state in which tumor cells are present, but tumor progression is not clinically apparent. Although clinical examples of tumor dormancy abound, little is known regarding the mechanisms underlying this state. Here we utilize an antibody-induced dormancy model of an aggressive murine B-cell lymphoma (BCL1) and show that the induction of the dormant state is accompanied by dramatic changes in tumor cell morphology and cell cycle status. These data indicate the feasibility of altering the malignant phenotype of transformed cells by specific signals originating at the cell surface, and they suggest new opportunities for therapeutic intervention in cancer.
UR - http://www.scopus.com/inward/record.url?scp=0027462883&partnerID=8YFLogxK
U2 - 10.1073/pnas.90.5.1829
DO - 10.1073/pnas.90.5.1829
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C2 - 8446596
AN - SCOPUS:0027462883
SN - 0027-8424
VL - 90
SP - 1829
EP - 1833
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 5
ER -
