Cancer dormancy: Isolation and characterization of dormant lymphoma cells

Eitan Yefenof; Louis J. Picker; Richard H. Scheuermann; Thomas F. Tucker; Ellen S. Vitetta; Jonathan W. Uhr

doi:10.1073/pnas.90.5.1829

Cancer dormancy: Isolation and characterization of dormant lymphoma cells

Eitan Yefenof
, Louis J. Picker
, Richard H. Scheuermann
, Thomas F. Tucker
, Ellen S. Vitetta
, Jonathan W. Uhr^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

"Tumor dormancy" is an operational term used to describe a prolonged quiescent state in which tumor cells are present, but tumor progression is not clinically apparent. Although clinical examples of tumor dormancy abound, little is known regarding the mechanisms underlying this state. Here we utilize an antibody-induced dormancy model of an aggressive murine B-cell lymphoma (BCL₁) and show that the induction of the dormant state is accompanied by dramatic changes in tumor cell morphology and cell cycle status. These data indicate the feasibility of altering the malignant phenotype of transformed cells by specific signals originating at the cell surface, and they suggest new opportunities for therapeutic intervention in cancer.

Original language	English
Pages (from-to)	1829-1833
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	90
Issue number	5
DOIs	https://doi.org/10.1073/pnas.90.5.1829
State	Published - 1 Mar 1993
Externally published	Yes

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10.1073/pnas.90.5.1829

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AU - Yefenof, Eitan

AU - Picker, Louis J.

AU - Scheuermann, Richard H.

AU - Tucker, Thomas F.

AU - Vitetta, Ellen S.

AU - Uhr, Jonathan W.

PY - 1993/3/1

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N2 - "Tumor dormancy" is an operational term used to describe a prolonged quiescent state in which tumor cells are present, but tumor progression is not clinically apparent. Although clinical examples of tumor dormancy abound, little is known regarding the mechanisms underlying this state. Here we utilize an antibody-induced dormancy model of an aggressive murine B-cell lymphoma (BCL1) and show that the induction of the dormant state is accompanied by dramatic changes in tumor cell morphology and cell cycle status. These data indicate the feasibility of altering the malignant phenotype of transformed cells by specific signals originating at the cell surface, and they suggest new opportunities for therapeutic intervention in cancer.

AB - "Tumor dormancy" is an operational term used to describe a prolonged quiescent state in which tumor cells are present, but tumor progression is not clinically apparent. Although clinical examples of tumor dormancy abound, little is known regarding the mechanisms underlying this state. Here we utilize an antibody-induced dormancy model of an aggressive murine B-cell lymphoma (BCL1) and show that the induction of the dormant state is accompanied by dramatic changes in tumor cell morphology and cell cycle status. These data indicate the feasibility of altering the malignant phenotype of transformed cells by specific signals originating at the cell surface, and they suggest new opportunities for therapeutic intervention in cancer.

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Cancer dormancy: Isolation and characterization of dormant lymphoma cells

Abstract

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