Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

Jeetendra Kumar Nag; Tatyana Rudina; Myriam Maoz; Sorina Grisaru-Granovsky; Beatrice Uziely; Rachel Bar-Shavit

doi:10.1007/s10555-017-9711-z

Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

Jeetendra Kumar Nag
, Tatyana Rudina
, Myriam Maoz
, Sorina Grisaru-Granovsky
, Beatrice Uziely
, Rachel Bar-Shavit^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) comprise the main signal-transmitting components in the cell membrane. Over the past several years, biochemical and structural analyses have immensely enhanced our knowledge of GPCR involvement in health and disease states. The present review focuses on GPCRs that are cancer drivers, involved in tumor growth and development. Our aim is to highlight the involvement of stabilized β-catenin molecular machinery with a specific array of GPCRs. We discuss recent advances in understanding the molecular path leading to β-catenin nuclear localization and transcriptional activity and their implications for future cancer therapy research.

Original language	English
Pages (from-to)	147-157
Number of pages	11
Journal	Cancer and Metastasis Reviews
Volume	37
Issue number	1
DOIs	https://doi.org/10.1007/s10555-017-9711-z
State	Published - 1 Mar 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media, LLC, part of Springer Nature.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
G protein-coupled receptors
β-catenin

Access to Document

10.1007/s10555-017-9711-z

Cite this

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abstract = "G protein-coupled receptors (GPCRs) comprise the main signal-transmitting components in the cell membrane. Over the past several years, biochemical and structural analyses have immensely enhanced our knowledge of GPCR involvement in health and disease states. The present review focuses on GPCRs that are cancer drivers, involved in tumor growth and development. Our aim is to highlight the involvement of stabilized β-catenin molecular machinery with a specific array of GPCRs. We discuss recent advances in understanding the molecular path leading to β-catenin nuclear localization and transcriptional activity and their implications for future cancer therapy research.",

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AU - Rudina, Tatyana

AU - Maoz, Myriam

AU - Grisaru-Granovsky, Sorina

AU - Uziely, Beatrice

AU - Bar-Shavit, Rachel

PY - 2018/3/1

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AB - G protein-coupled receptors (GPCRs) comprise the main signal-transmitting components in the cell membrane. Over the past several years, biochemical and structural analyses have immensely enhanced our knowledge of GPCR involvement in health and disease states. The present review focuses on GPCRs that are cancer drivers, involved in tumor growth and development. Our aim is to highlight the involvement of stabilized β-catenin molecular machinery with a specific array of GPCRs. We discuss recent advances in understanding the molecular path leading to β-catenin nuclear localization and transcriptional activity and their implications for future cancer therapy research.

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KW - G protein-coupled receptors

KW - β-catenin

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IS - 1

ER -

Cancer driver G-protein coupled receptor (GPCR) induced β-catenin nuclear localization: the transcriptional junction

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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