TY - JOUR
T1 - Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells
AU - Avior, Yishai
AU - Eggan, Kevin
AU - Benvenisty, Nissim
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10/3
Y1 - 2019/10/3
N2 - Human pluripotent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential. We established a strategy to identify cancer-related point mutations in hPSCs, detecting recurrent mutations in over 20 genes, alongside those previously detected in p53. Importantly, naive hPSCs harbor, on average, four times more mutations than their primed counterparts, which appear primarily in pathways inhibited during naive conversion. Such cancer-related mutations should be taken into consideration in future applications, especially in clinical contexts.
AB - Human pluripotent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential. We established a strategy to identify cancer-related point mutations in hPSCs, detecting recurrent mutations in over 20 genes, alongside those previously detected in p53. Importantly, naive hPSCs harbor, on average, four times more mutations than their primed counterparts, which appear primarily in pathways inhibited during naive conversion. Such cancer-related mutations should be taken into consideration in future applications, especially in clinical contexts.
UR - http://www.scopus.com/inward/record.url?scp=85072715971&partnerID=8YFLogxK
U2 - 10.1016/j.stem.2019.09.001
DO - 10.1016/j.stem.2019.09.001
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C2 - 31543368
AN - SCOPUS:85072715971
SN - 1934-5909
VL - 25
SP - 456
EP - 461
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 4
ER -
