Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells

Yishai Avior, Kevin Eggan, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

15 Scopus citations

Abstract

Human pluripotent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential. We established a strategy to identify cancer-related point mutations in hPSCs, detecting recurrent mutations in over 20 genes, alongside those previously detected in p53. Importantly, naive hPSCs harbor, on average, four times more mutations than their primed counterparts, which appear primarily in pathways inhibited during naive conversion. Such cancer-related mutations should be taken into consideration in future applications, especially in clinical contexts.

Original languageAmerican English
Pages (from-to)456-461
Number of pages6
JournalCell Stem Cell
Volume25
Issue number4
DOIs
StatePublished - 3 Oct 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

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