Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells

Yishai Avior; Kevin Eggan; Nissim Benvenisty

doi:10.1016/j.stem.2019.09.001

Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells

Yishai Avior
, Kevin Eggan
, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Human pluripotent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential. We established a strategy to identify cancer-related point mutations in hPSCs, detecting recurrent mutations in over 20 genes, alongside those previously detected in p53. Importantly, naive hPSCs harbor, on average, four times more mutations than their primed counterparts, which appear primarily in pathways inhibited during naive conversion. Such cancer-related mutations should be taken into consideration in future applications, especially in clinical contexts.

Original language	English
Pages (from-to)	456-461
Number of pages	6
Journal	Cell Stem Cell
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2019.09.001
State	Published - 3 Oct 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

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10.1016/j.stem.2019.09.001

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abstract = "Human pluripotent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential. We established a strategy to identify cancer-related point mutations in hPSCs, detecting recurrent mutations in over 20 genes, alongside those previously detected in p53. Importantly, naive hPSCs harbor, on average, four times more mutations than their primed counterparts, which appear primarily in pathways inhibited during naive conversion. Such cancer-related mutations should be taken into consideration in future applications, especially in clinical contexts.",

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Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells

Abstract

Bibliographical note

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