Cancer risks among BRCA1 and BRCA2 mutation carriers

E. Levy-Lahad; E. Friedman

doi:10.1038/sj.bjc.6603535

Cancer risks among BRCA1 and BRCA2 mutation carriers

E. Levy-Lahad^*
, E. Friedman

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Short survey › peer-review

277 Scopus citations

Abstract

BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	British Journal of Cancer
Volume	96
Issue number	1
DOIs	https://doi.org/10.1038/sj.bjc.6603535
State	Published - 15 Jan 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BRCA1
BRCA2
Breast cancer
Ovarian cancer
Penetrance

Access to Document

10.1038/sj.bjc.6603535

Cite this

@article{444efa13393e459a9d57eef0004fc2a2,

title = "Cancer risks among BRCA1 and BRCA2 mutation carriers",

abstract = "BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.",

keywords = "BRCA1, BRCA2, Breast cancer, Ovarian cancer, Penetrance",

author = "E. Levy-Lahad and E. Friedman",

year = "2007",

month = jan,

day = "15",

doi = "10.1038/sj.bjc.6603535",

language = "אנגלית",

volume = "96",

pages = "11--15",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Cancer risks among BRCA1 and BRCA2 mutation carriers

AU - Levy-Lahad, E.

AU - Friedman, E.

PY - 2007/1/15

Y1 - 2007/1/15

N2 - BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

AB - BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

KW - BRCA1

KW - BRCA2

KW - Breast cancer

KW - Ovarian cancer

KW - Penetrance

UR - https://www.scopus.com/pages/publications/33846203984

U2 - 10.1038/sj.bjc.6603535

DO - 10.1038/sj.bjc.6603535

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.shortsurvey???

C2 - 17213823

AN - SCOPUS:33846203984

SN - 0007-0920

VL - 96

SP - 11

EP - 15

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 1

ER -

Cancer risks among BRCA1 and BRCA2 mutation carriers

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this