TY - JOUR
T1 - Canine leishmaniosis - new concepts and insights on an expanding zoonosis
T2 - part one
AU - Baneth, Gad
AU - Koutinas, Alexander F.
AU - Solano-Gallego, Laia
AU - Bourdeau, Patrick
AU - Ferrer, Lluis
PY - 2008/7
Y1 - 2008/7
N2 - Recent research has provided new insights on the epidemiology, pathology and immunology of canine leishmaniosis (CanL) and its genetic basis. The prevalence of infection in endemic areas is considerably higher than that of apparent clinical illness. In addition, infection spreads rapidly among dogs in the presence of optimal conditions for transmission. Infection involves a variety of granulomatous and harmful immune-mediated responses, and susceptibility to the disease is influenced by a complex genetic basis. These concepts will be instrumental for devising control programs. This review, the first in a series of two articles on CanL, presents an updated view on progress in elucidating the epidemiology and pathogenesis of this challenging disease, and the second part focuses on advances in diagnosis, treatment and prevention.
AB - Recent research has provided new insights on the epidemiology, pathology and immunology of canine leishmaniosis (CanL) and its genetic basis. The prevalence of infection in endemic areas is considerably higher than that of apparent clinical illness. In addition, infection spreads rapidly among dogs in the presence of optimal conditions for transmission. Infection involves a variety of granulomatous and harmful immune-mediated responses, and susceptibility to the disease is influenced by a complex genetic basis. These concepts will be instrumental for devising control programs. This review, the first in a series of two articles on CanL, presents an updated view on progress in elucidating the epidemiology and pathogenesis of this challenging disease, and the second part focuses on advances in diagnosis, treatment and prevention.
UR - http://www.scopus.com/inward/record.url?scp=45449085832&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2008.04.001
DO - 10.1016/j.pt.2008.04.001
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C2 - 18514028
AN - SCOPUS:45449085832
SN - 1471-4922
VL - 24
SP - 324
EP - 330
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 7
ER -