TY - JOUR
T1 - Canine leishmaniosis - new concepts and insights on an expanding zoonosis
T2 - part two
AU - Miró, Guadalupe
AU - Cardoso, Luis
AU - Pennisi, Maria Grazia
AU - Oliva, Gaetano
AU - Baneth, Gad
PY - 2008/8
Y1 - 2008/8
N2 - Canine leishmaniosis is a widely spread zoonosis that is potentially fatal to humans and dogs. Infection with Leishmania infantum is considerably more prevalent than clinical disease, and infected dogs with no signs of disease might, potentially, transmit infection. Diagnosis of asymptomatic infection by serology is insufficient and PCR markedly increases its sensitivity. A new therapy exclusively for canine leishmaniosis is needed because current drugs do not reliably eliminate infection and might provoke resistance. Protection against sand-fly bites by topical insecticides is effective in reducing infection, and recent development of vaccines has indicated that prevention by vaccination is feasible. Integrated prevention with topical insecticides reducing the feeding of vectors and vaccination blocking early infection would be the basis of successful control programs.
AB - Canine leishmaniosis is a widely spread zoonosis that is potentially fatal to humans and dogs. Infection with Leishmania infantum is considerably more prevalent than clinical disease, and infected dogs with no signs of disease might, potentially, transmit infection. Diagnosis of asymptomatic infection by serology is insufficient and PCR markedly increases its sensitivity. A new therapy exclusively for canine leishmaniosis is needed because current drugs do not reliably eliminate infection and might provoke resistance. Protection against sand-fly bites by topical insecticides is effective in reducing infection, and recent development of vaccines has indicated that prevention by vaccination is feasible. Integrated prevention with topical insecticides reducing the feeding of vectors and vaccination blocking early infection would be the basis of successful control programs.
UR - http://www.scopus.com/inward/record.url?scp=47849109026&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2008.05.003
DO - 10.1016/j.pt.2008.05.003
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C2 - 18603476
AN - SCOPUS:47849109026
SN - 1471-4922
VL - 24
SP - 371
EP - 377
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 8
ER -