TY - JOUR
T1 - Cannabidiol
T2 - An overview of some chemical and pharmacological aspects. Part I: Chemical aspects
AU - Mechoulam, Raphael
AU - Hanuš, Lumír
PY - 2002/12/31
Y1 - 2002/12/31
N2 - Over the last few years considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of Cannabis. In Part I of this review we present a condensed survey of the chemistry of CBD; in Part II, to be published later, we shall discuss the anti-convulsive, anti-anxiety, anti-psychotic, anti-nausea and anti-rheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors and its mechanism of action is yet unknown. In Part II we shall also present evidence that it is conceivable that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its anti-oxidative effect.
AB - Over the last few years considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of Cannabis. In Part I of this review we present a condensed survey of the chemistry of CBD; in Part II, to be published later, we shall discuss the anti-convulsive, anti-anxiety, anti-psychotic, anti-nausea and anti-rheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors and its mechanism of action is yet unknown. In Part II we shall also present evidence that it is conceivable that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its anti-oxidative effect.
KW - Cannabidiol
KW - Cannabis
KW - Chemical and pharmacological aspects
UR - http://www.scopus.com/inward/record.url?scp=0037207079&partnerID=8YFLogxK
U2 - 10.1016/S0009-3084(02)00144-5
DO - 10.1016/S0009-3084(02)00144-5
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C2 - 12505688
AN - SCOPUS:0037207079
SN - 0009-3084
VL - 121
SP - 35
EP - 43
JO - Chemistry and Physics of Lipids
JF - Chemistry and Physics of Lipids
IS - 1-2
ER -