Cannabidiol: An overview of some chemical and pharmacological aspects. Part I: Chemical aspects

Raphael Mechoulam*, Lumír Hanuš

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

223 Scopus citations

Abstract

Over the last few years considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of Cannabis. In Part I of this review we present a condensed survey of the chemistry of CBD; in Part II, to be published later, we shall discuss the anti-convulsive, anti-anxiety, anti-psychotic, anti-nausea and anti-rheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors and its mechanism of action is yet unknown. In Part II we shall also present evidence that it is conceivable that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its anti-oxidative effect.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalChemistry and Physics of Lipids
Volume121
Issue number1-2
DOIs
StatePublished - 31 Dec 2002

Keywords

  • Cannabidiol
  • Cannabis
  • Chemical and pharmacological aspects

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