Cannabidiol: An overview of some pharmacological aspects

Raphael Mechoulam*, Linda A. Parker, Ruth Gallily

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

410 Scopus citations

Abstract

Over the past few years, considerable attention has focused on cannabidiol (CBD), a major nonpsychotropic constituent of cannabis. The authors present a review on the chemistry of CBD and discuss the anticonvulsive, antianxiety, antipsychotic, antinausea, and antirheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors, and its mechanism of action is yet unknown. It is possible that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its antioxidative effect.

Original languageEnglish
Pages (from-to)11S-19S
JournalJournal of Clinical Pharmacology
Volume42
Issue number11 SUPPL.
DOIs
StatePublished - 1 Nov 2002

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