Cannabidiol and Phenytoin: A Structural Comparison

Ilana Tamir; Raphael Mechoulam; Amatzya Y. Meyer

doi:10.1021/jm00176a022

Cannabidiol and Phenytoin: A Structural Comparison

Ilana Tamir, Raphael Mechoulam, Amatzya Y. Meyer

Research output: Contribution to journal › Article › peer-review

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Abstract

Conformational energy maps have been computed for the antiepileptic agents phenytoin and cannabidiol by the quantum-mechanical method of perturbative configuration interaction with localized orbitals (PCILO). The computation indicates that the spatial relationship between the two rings in the two drugs is similar and close to the respective structures in the crystal. This is supported by ^lH and ¹³C NMR measurements. Hence, both compounds fulfill the stereochemical requirements suggested for anticonvulsant drug action.

Original language	English
Pages (from-to)	220-223
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	23
Issue number	2
DOIs	https://doi.org/10.1021/jm00176a022
State	Published - 1 Feb 1980
Externally published	Yes

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Cannabidiol and Phenytoin: A Structural Comparison

Abstract

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