Cannabidiol (CBD) is a major non-psychotropic constituent of Cannabis sativa, with well recognized therapeutic potential. Considering the importance of the endogenous cannabinoid system to the regulation of food intake and energy balance we studied the effects of repeated CBD administration on body weight gains in rats. Male Wistar rats (260±20 g at start of study) received intraperitoneal injections of CBD at doses of 2.5 and 5 mg/kg/day for 14 consecutive days and body weight gains were monitored. Both doses of CBD produced significant decrease in body weight gain, with the effect produced by 5 mg/kg being more pronounced. The CB2 receptor selective antagonist, AM630, blocked the decrease in body weight gain. AM630 alone did not affect body weight gain. The results suggest that CBD has the ability to alter body weight gain, possibly via the CB2 receptor. CB2 receptors may play a role in the regulation of body weight and the effects of CB2 specific ligands should be further investigated in studies of body weight regulation.
Bibliographical noteFunding Information:
This research was supported by Polish Ministry of Science and Higher Education Predoctoral Research Grants N N303 394036 and N N303 417137 to B. Ignatowska-Jankowska and M. Jankowski. Research was partly financed by the European Union within the European Social Fund in the framework of the project “InnoDoktorant – Scholarships for PhD students, I edition”, and the Program of implementing the elements of modern education forms at the University of Gdansk, task: Research grants for PhD students – a chance for the economic development. Research was also supported by the Foundation for Polish Science Ventures Programme (Ventures/2009-4/3) co-financed by the EU European Regional Development Fund . Artur H. Swiergiel's research is supported by the University of Gdansk and the project “Centre of Excellence in Genomics, Biotechnology and Quality of Animal Products in Sustainable Production Systems with consideration of Animal Welfare – ANIMBIOGEN in EU” which has received European Community research funding ( FP7-REGPOT-2008-1 , GA no. 229915). Finally, the authors would like to thank National Institute on Drug Abuse (NIDA), USA, for drug supply.
- Body weight
- CB2 receptor