Cannabinoid quinones—a review and novel observations

Natalya M. Kogan*, Maximilian Peters, Raphael Mechoulam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A cannabinoid anticancer para-quinone, HU-331, which was synthesized by our group five decades ago, was shown to have very high efficacy against human cancer cell lines in-vitro and against in-vivo grafts of human tumors in nude mice. The main mechanism was topoisomerase IIα catalytic inhibition. Later, several groups synthesized related compounds. In the present presentation, we review the publications on compounds synthesized on the basis of HU-331, summarize their published activities and mechanisms of action and report the synthesis and action of novel quinones, thus expanding the structure-activity relationship in these series.

Original languageAmerican English
Article number1761
JournalMolecules
Volume26
Issue number6
DOIs
StatePublished - 21 Mar 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Anti-cancer
  • Cannabinoid
  • Quinones
  • Structure-activity relationship

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