TY - JOUR
T1 - Cannabinoids and brain injury
T2 - Therapeutic implications
AU - Mechoulam, Raphael
AU - Panikashvili, David
AU - Shohami, Esther
PY - 2002
Y1 - 2002
N2 - Mounting in vitro and in vivo data suggest that the WP anandamide and 2-arachidonoyl glycerol, as well as some plant and synthetic cannabinoids, have neuroprotective effects following brain injury. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission and reduce the production of tumour necrosis factor-α and reactive oxygen intermediates, which are factors in causing neuronal damage. The formation of the annabinoid anandamide and 2-arachidonoyl glycerol is strongly enhanced after brain injury, and there is evidence that these compounds reduce the secondary damage incurred. Some plant and synthetic cannabinoids, which do not bind to the cannabinoid receptors, have also been shown to be neuroprotective, possibly through their direct effect on the excitatory glutamate system and/or as antioxidants.
AB - Mounting in vitro and in vivo data suggest that the WP anandamide and 2-arachidonoyl glycerol, as well as some plant and synthetic cannabinoids, have neuroprotective effects following brain injury. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission and reduce the production of tumour necrosis factor-α and reactive oxygen intermediates, which are factors in causing neuronal damage. The formation of the annabinoid anandamide and 2-arachidonoyl glycerol is strongly enhanced after brain injury, and there is evidence that these compounds reduce the secondary damage incurred. Some plant and synthetic cannabinoids, which do not bind to the cannabinoid receptors, have also been shown to be neuroprotective, possibly through their direct effect on the excitatory glutamate system and/or as antioxidants.
UR - http://www.scopus.com/inward/record.url?scp=0036156353&partnerID=8YFLogxK
U2 - 10.1016/S1471-4914(02)02276-1
DO - 10.1016/S1471-4914(02)02276-1
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C2 - 11815270
AN - SCOPUS:0036156353
SN - 1471-4914
VL - 8
SP - 58
EP - 61
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 2
ER -