Capsule around silicone implants in diabetic rats: Histological and biochemical study

I. J. Peled; M. R. Wexler; S. Shoshan; S. B. Moshe; D. Gazit; I. Bab; S. Ticher

doi:10.1097/00000637-198610000-00004

Capsule around silicone implants in diabetic rats: Histological and biochemical study

I. J. Peled, M. R. Wexler, S. Shoshan, S. B. Moshe, D. Gazit, I. Bab, S. Ticher

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Polydimethylsiloxane (silicone) implants were subcutaneously placed in the back of diabetic and normal rats. After three months the rats were killed and the fibrous capsule around the implants was histologically and biochemically examined. A significant quantitative difference (p < 0.001) was found in the thickness of the capsules, which were two to three times thicker in the diabetic animals. The biochemistry showed an increase of neutral salt-soluble collagen in the diabetic group; electrophoresis revealed only type I collagen in the diabetic and type I and III in the normal rats. From this experimental trial it seems that diabetes mellitus is another factor in formation of a thick capsule around silicone implants.

Original language	English
Pages (from-to)	288-291
Number of pages	4
Journal	Annals of Plastic Surgery
Volume	17
Issue number	4
DOIs	https://doi.org/10.1097/00000637-198610000-00004
State	Published - 1986

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10.1097/00000637-198610000-00004

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abstract = "Polydimethylsiloxane (silicone) implants were subcutaneously placed in the back of diabetic and normal rats. After three months the rats were killed and the fibrous capsule around the implants was histologically and biochemically examined. A significant quantitative difference (p < 0.001) was found in the thickness of the capsules, which were two to three times thicker in the diabetic animals. The biochemistry showed an increase of neutral salt-soluble collagen in the diabetic group; electrophoresis revealed only type I collagen in the diabetic and type I and III in the normal rats. From this experimental trial it seems that diabetes mellitus is another factor in formation of a thick capsule around silicone implants.",

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AU - Peled, I. J.

AU - Wexler, M. R.

AU - Shoshan, S.

AU - Moshe, S. B.

AU - Gazit, D.

AU - Bab, I.

AU - Ticher, S.

PY - 1986

Y1 - 1986

N2 - Polydimethylsiloxane (silicone) implants were subcutaneously placed in the back of diabetic and normal rats. After three months the rats were killed and the fibrous capsule around the implants was histologically and biochemically examined. A significant quantitative difference (p < 0.001) was found in the thickness of the capsules, which were two to three times thicker in the diabetic animals. The biochemistry showed an increase of neutral salt-soluble collagen in the diabetic group; electrophoresis revealed only type I collagen in the diabetic and type I and III in the normal rats. From this experimental trial it seems that diabetes mellitus is another factor in formation of a thick capsule around silicone implants.

AB - Polydimethylsiloxane (silicone) implants were subcutaneously placed in the back of diabetic and normal rats. After three months the rats were killed and the fibrous capsule around the implants was histologically and biochemically examined. A significant quantitative difference (p < 0.001) was found in the thickness of the capsules, which were two to three times thicker in the diabetic animals. The biochemistry showed an increase of neutral salt-soluble collagen in the diabetic group; electrophoresis revealed only type I collagen in the diabetic and type I and III in the normal rats. From this experimental trial it seems that diabetes mellitus is another factor in formation of a thick capsule around silicone implants.

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JO - Annals of Plastic Surgery

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Capsule around silicone implants in diabetic rats: Histological and biochemical study

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