Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

Raphael Mechoulam; Ester Fride; Shimon Ben-Shabat; Uri Meiri; Michal Horowitz

doi:10.1016/S0014-2999(98)00777-8

Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

Raphael Mechoulam^*
, Ester Fride
, Shimon Ben-Shabat
, Uri Meiri
, Michal Horowitz

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.

Original language	English
Pages (from-to)	R1-R3
Journal	European Journal of Pharmacology
Volume	362
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00777-8
State	Published - 27 Nov 1998

Keywords

2-Arachidonoyl glycerol
Cannabinoid
Hypotension

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10.1016/S0014-2999(98)00777-8

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AU - Mechoulam, Raphael

AU - Fride, Ester

AU - Ben-Shabat, Shimon

AU - Meiri, Uri

AU - Horowitz, Michal

PY - 1998/11/27

Y1 - 1998/11/27

N2 - The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.

AB - The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.

KW - 2-Arachidonoyl glycerol

KW - Cannabinoid

KW - Hypotension

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ER -

Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

Abstract

Keywords

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