TY - JOUR
T1 - Carbon dioxide-catalyzed peroxynitrite reactivity – The resilience of the radical mechanism after two decades of research
AU - Augusto, Ohara
AU - Goldstein, Sara
AU - Hurst, James K.
AU - Lind, Johan
AU - Lymar, Sergei V.
AU - Merenyi, Gabor
AU - Radi, Rafael
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Peroxynitrite, ONOO − , formed in tissues that are simultaneously generating NO • and O 2 •- , is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO 2 via formation of an unstable adduct, ONOOC(O)O − , that undergoes O-O bond homolysis to produce NO 2 • and CO 3 •– radicals, whose yields are equal at about 0.33 with respect to the ONOO − reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these [Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31:721-730; 2018] claims that ONOOC(O)O − is stable, predicts a yield of NO 2 • /CO 3 •– of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect.
AB - Peroxynitrite, ONOO − , formed in tissues that are simultaneously generating NO • and O 2 •- , is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO 2 via formation of an unstable adduct, ONOOC(O)O − , that undergoes O-O bond homolysis to produce NO 2 • and CO 3 •– radicals, whose yields are equal at about 0.33 with respect to the ONOO − reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these [Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31:721-730; 2018] claims that ONOOC(O)O − is stable, predicts a yield of NO 2 • /CO 3 •– of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect.
UR - http://www.scopus.com/inward/record.url?scp=85063040223&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2019.02.026
DO - 10.1016/j.freeradbiomed.2019.02.026
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C2 - 30818056
AN - SCOPUS:85063040223
SN - 0891-5849
VL - 135
SP - 210
EP - 215
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -