Carcinoid myopathy and treatment with cyproheptadine (Periactin)

Elliot M. Berry; Caroline Maunder; Marie Wilson

doi:10.1136/gut.15.1.34

Carcinoid myopathy and treatment with cyproheptadine (Periactin)

Elliot M. Berry, Caroline Maunder, Marie Wilson

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A case of the carcinoid syndrome associated with a proximal myopathy is reported. Histology showed advanced atrophy of type II muscle fibres but no inflammation. Perinuclear acid phosphatase was increased. Electron microscopy revealed persistence of the Z-line until the muscle fibre had been severely disrupted. Similar lesions have been observed in the hereditary muscular dystrophy in mice, and also in these animals and in rats when injected with 5-hydroxytryptamine (5-HT). Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power. We suggest that the myopathy is due to circulating 5-HT or is a non-metastatic complication of the carcinoid tumour.

Original language	American English
Pages (from-to)	34-38
Journal	Gut
Volume	15
Issue number	1
DOIs	https://doi.org/10.1136/gut.15.1.34
State	Published - 1 Jan 1974

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http://gut.bmj.com/content/15/1/34.abstract

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title = "Carcinoid myopathy and treatment with cyproheptadine (Periactin)",

abstract = "A case of the carcinoid syndrome associated with a proximal myopathy is reported. Histology showed advanced atrophy of type II muscle fibres but no inflammation. Perinuclear acid phosphatase was increased. Electron microscopy revealed persistence of the Z-line until the muscle fibre had been severely disrupted. Similar lesions have been observed in the hereditary muscular dystrophy in mice, and also in these animals and in rats when injected with 5-hydroxytryptamine (5-HT). Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power. We suggest that the myopathy is due to circulating 5-HT or is a non-metastatic complication of the carcinoid tumour.",

author = "Berry, {Elliot M.} and Caroline Maunder and Marie Wilson",

year = "1974",

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doi = "10.1136/gut.15.1.34",

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T1 - Carcinoid myopathy and treatment with cyproheptadine (Periactin)

AU - Berry, Elliot M.

AU - Maunder, Caroline

AU - Wilson, Marie

PY - 1974/1/1

Y1 - 1974/1/1

N2 - A case of the carcinoid syndrome associated with a proximal myopathy is reported. Histology showed advanced atrophy of type II muscle fibres but no inflammation. Perinuclear acid phosphatase was increased. Electron microscopy revealed persistence of the Z-line until the muscle fibre had been severely disrupted. Similar lesions have been observed in the hereditary muscular dystrophy in mice, and also in these animals and in rats when injected with 5-hydroxytryptamine (5-HT). Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power. We suggest that the myopathy is due to circulating 5-HT or is a non-metastatic complication of the carcinoid tumour.

AB - A case of the carcinoid syndrome associated with a proximal myopathy is reported. Histology showed advanced atrophy of type II muscle fibres but no inflammation. Perinuclear acid phosphatase was increased. Electron microscopy revealed persistence of the Z-line until the muscle fibre had been severely disrupted. Similar lesions have been observed in the hereditary muscular dystrophy in mice, and also in these animals and in rats when injected with 5-hydroxytryptamine (5-HT). Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power. We suggest that the myopathy is due to circulating 5-HT or is a non-metastatic complication of the carcinoid tumour.

U2 - 10.1136/gut.15.1.34

DO - 10.1136/gut.15.1.34

M3 - Article

SN - 0017-5749

VL - 15

SP - 34

EP - 38

JO - Gut

JF - Gut

IS - 1

ER -

Carcinoid myopathy and treatment with cyproheptadine (Periactin)

Abstract

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