Cardiac allograft survival in mice treated with IL-2-PE40

H. Lorberboum-Galski, L. V. Barrett, R. L. Kirkman, M. Ogata, M. C. Willingham, D. J. FitzGerald, I. Pastan

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

IL-2-PE40 is a chimeric protein composed of human interleukin 2 (IL-2) genetically fused to the amino terminus of a modified form of Pseudomonas exotoxin lacking its cell recognition domain. IL-2-PE40, which is extremely cytotoxic to IL-2 receptor-positive cells, was examined for its ability to prevent graft rejection in mice in which activation of T cells is prominent. We demonstrate that intraperitoneally administered IL-2-PE40 specifically and significantly prolongs the survival of vascularized heart allografts in mice. The chimeric toxin, IL-2-PE40, offers an alternative approach to the treatment of autoimmune diseases and transplant rejection in humans.

Original languageAmerican English
Pages (from-to)1008-1012
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

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