Cardiovascular pathology induced by passive transfer of splenic cells from syngeneic rats treated with T-2 toxin

Y. Sherman; R. More; B. Yagen; R. Yarom

doi:10.1016/0378-4274(87)90036-1

Cardiovascular pathology induced by passive transfer of splenic cells from syngeneic rats treated with T-2 toxin

Y. Sherman, R. More, B. Yagen, R. Yarom^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Mononuclear cells were separated from spleens and lymph nodes of Lewis rats treated 5 weeks previously with repeated small doses of T-2 toxin or solvent only. The cells from each site were then injected intraperitoneally into 4 groups of syngeneic Lewis rats. The animals injected with spleen cells from T-2 toxin-treated donors developed marked cardiovascular changes which were similar to those due to T-2 toxin itself. Rats injected with lymph node cells as well as those given each kind of cell from solvent-treated donors showed only occasional mild vascular changes. The changes seen after splenic cell transfer may be due to superinduction of interleukin 2 by T-2 toxin.

Original language	English
Pages (from-to)	15-22
Number of pages	8
Journal	Toxicology Letters
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(87)90036-1
State	Published - Mar 1987

Keywords

T-2 toxin
cardiovascular effects
lymphocyte toxicity
rat

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10.1016/0378-4274(87)90036-1

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abstract = "Mononuclear cells were separated from spleens and lymph nodes of Lewis rats treated 5 weeks previously with repeated small doses of T-2 toxin or solvent only. The cells from each site were then injected intraperitoneally into 4 groups of syngeneic Lewis rats. The animals injected with spleen cells from T-2 toxin-treated donors developed marked cardiovascular changes which were similar to those due to T-2 toxin itself. Rats injected with lymph node cells as well as those given each kind of cell from solvent-treated donors showed only occasional mild vascular changes. The changes seen after splenic cell transfer may be due to superinduction of interleukin 2 by T-2 toxin.",

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AU - More, R.

AU - Yagen, B.

AU - Yarom, R.

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N2 - Mononuclear cells were separated from spleens and lymph nodes of Lewis rats treated 5 weeks previously with repeated small doses of T-2 toxin or solvent only. The cells from each site were then injected intraperitoneally into 4 groups of syngeneic Lewis rats. The animals injected with spleen cells from T-2 toxin-treated donors developed marked cardiovascular changes which were similar to those due to T-2 toxin itself. Rats injected with lymph node cells as well as those given each kind of cell from solvent-treated donors showed only occasional mild vascular changes. The changes seen after splenic cell transfer may be due to superinduction of interleukin 2 by T-2 toxin.

AB - Mononuclear cells were separated from spleens and lymph nodes of Lewis rats treated 5 weeks previously with repeated small doses of T-2 toxin or solvent only. The cells from each site were then injected intraperitoneally into 4 groups of syngeneic Lewis rats. The animals injected with spleen cells from T-2 toxin-treated donors developed marked cardiovascular changes which were similar to those due to T-2 toxin itself. Rats injected with lymph node cells as well as those given each kind of cell from solvent-treated donors showed only occasional mild vascular changes. The changes seen after splenic cell transfer may be due to superinduction of interleukin 2 by T-2 toxin.

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KW - lymphocyte toxicity

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Cardiovascular pathology induced by passive transfer of splenic cells from syngeneic rats treated with T-2 toxin

Abstract

Keywords

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