Carriers for skin delivery of trihexyphenidyl HCl: Ethosomes vs. liposomes

Nava Dayan, Elka Touitou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

434 Scopus citations

Abstract

The purpose of this work was to characterize a novel ethosomal carrier containing trihexyphenidyl HCl (THP) and to investigate the delivery of THP from ethosomes versus classic liposomes. THP-ethosomal systems were shown by electron microscopy to contain small, phospholipid vesicles. As the THP concentration was increased from 0 to 3%, the size of the vesicles decreased from 154 to 90nm. This is most likely due to the surface activity of THP (critical micelle concentration of 5.9mg/ml), as measured in this work. In addition, the ethosome zeta potential value increased as a function of THP concentration, from -4.5 to +10.4 when the THP concentration was increased from 0 to 3%. In contrast, THP liposomes were much larger and their charge was not affected by THP. When compared with standard liposomes, ethosomes had a higher entrapment capacity and a greater ability to deliver entrapped fluorescent probe to the deeper layers of skin. The flux of THP through nude mouse skin from THP ethosomes (0.21mg/cm2h) was 87, 51 and 4.5 times higher than from liposomes, phosphate buffer and hydroethanolic solution, respectively (p<0.01). The quantity of THP remaining in the skin at the end of the 18-h experiment was statistically significantly greater from the ethosomal system than from liposomes or a control hydroethanolic solution. Our results indicate that the ethosomal THP system may be a promising candidate for transdermal delivery of THP. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)1879-1885
Number of pages7
JournalBiomaterials
Volume21
Issue number18
DOIs
StatePublished - Sep 2000

Keywords

  • Ethosomes
  • Liposomes
  • Parkinson
  • Permeation enhancement
  • Skin
  • Surface activity
  • Transdermal delivery
  • Trihexyphenidyl

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