TY - JOUR
T1 - Carriers for skin delivery of trihexyphenidyl HCl
T2 - Ethosomes vs. liposomes
AU - Dayan, Nava
AU - Touitou, Elka
PY - 2000/9
Y1 - 2000/9
N2 - The purpose of this work was to characterize a novel ethosomal carrier containing trihexyphenidyl HCl (THP) and to investigate the delivery of THP from ethosomes versus classic liposomes. THP-ethosomal systems were shown by electron microscopy to contain small, phospholipid vesicles. As the THP concentration was increased from 0 to 3%, the size of the vesicles decreased from 154 to 90nm. This is most likely due to the surface activity of THP (critical micelle concentration of 5.9mg/ml), as measured in this work. In addition, the ethosome zeta potential value increased as a function of THP concentration, from -4.5 to +10.4 when the THP concentration was increased from 0 to 3%. In contrast, THP liposomes were much larger and their charge was not affected by THP. When compared with standard liposomes, ethosomes had a higher entrapment capacity and a greater ability to deliver entrapped fluorescent probe to the deeper layers of skin. The flux of THP through nude mouse skin from THP ethosomes (0.21mg/cm2h) was 87, 51 and 4.5 times higher than from liposomes, phosphate buffer and hydroethanolic solution, respectively (p<0.01). The quantity of THP remaining in the skin at the end of the 18-h experiment was statistically significantly greater from the ethosomal system than from liposomes or a control hydroethanolic solution. Our results indicate that the ethosomal THP system may be a promising candidate for transdermal delivery of THP. Copyright (C) 2000 Elsevier Science B.V.
AB - The purpose of this work was to characterize a novel ethosomal carrier containing trihexyphenidyl HCl (THP) and to investigate the delivery of THP from ethosomes versus classic liposomes. THP-ethosomal systems were shown by electron microscopy to contain small, phospholipid vesicles. As the THP concentration was increased from 0 to 3%, the size of the vesicles decreased from 154 to 90nm. This is most likely due to the surface activity of THP (critical micelle concentration of 5.9mg/ml), as measured in this work. In addition, the ethosome zeta potential value increased as a function of THP concentration, from -4.5 to +10.4 when the THP concentration was increased from 0 to 3%. In contrast, THP liposomes were much larger and their charge was not affected by THP. When compared with standard liposomes, ethosomes had a higher entrapment capacity and a greater ability to deliver entrapped fluorescent probe to the deeper layers of skin. The flux of THP through nude mouse skin from THP ethosomes (0.21mg/cm2h) was 87, 51 and 4.5 times higher than from liposomes, phosphate buffer and hydroethanolic solution, respectively (p<0.01). The quantity of THP remaining in the skin at the end of the 18-h experiment was statistically significantly greater from the ethosomal system than from liposomes or a control hydroethanolic solution. Our results indicate that the ethosomal THP system may be a promising candidate for transdermal delivery of THP. Copyright (C) 2000 Elsevier Science B.V.
KW - Ethosomes
KW - Liposomes
KW - Parkinson
KW - Permeation enhancement
KW - Skin
KW - Surface activity
KW - Transdermal delivery
KW - Trihexyphenidyl
UR - http://www.scopus.com/inward/record.url?scp=0034119958&partnerID=8YFLogxK
U2 - 10.1016/S0142-9612(00)00063-6
DO - 10.1016/S0142-9612(00)00063-6
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C2 - 10919691
AN - SCOPUS:0034119958
SN - 0142-9612
VL - 21
SP - 1879
EP - 1885
JO - Biomaterials
JF - Biomaterials
IS - 18
ER -