Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction: Rapid assembly of spiranoid lactones

Ghassan Albarghouti; Ramesh Kotikalapudi; David Lankri; Viviana Valerio; Dmitry Tsvelikhovsky

doi:10.1039/c5cc09923d

Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction: Rapid assembly of spiranoid lactones

Ghassan Albarghouti
, Ramesh Kotikalapudi
, David Lankri
, Viviana Valerio
, Dmitry Tsvelikhovsky^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.

Original language	English
Pages (from-to)	3095-3098
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	15
DOIs	https://doi.org/10.1039/c5cc09923d
State	Published - 2016

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Publisher Copyright:
© The Royal Society of Chemistry 2016.

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10.1039/c5cc09923d

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abstract = "An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.",

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AU - Albarghouti, Ghassan

AU - Kotikalapudi, Ramesh

AU - Lankri, David

AU - Valerio, Viviana

AU - Tsvelikhovsky, Dmitry

PY - 2016

Y1 - 2016

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AB - An unprecedented Pd-catalyzed cascade Wacker-Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.

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Cascade Pd(ii)-catalyzed Wacker lactonization-Heck reaction: Rapid assembly of spiranoid lactones

Abstract

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