Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Sarah Israel*, Hila Elinav, Ram Elazary, Daniel Porat, Roni Gibori, Arik Dahan, Carmil Azran, Ehud Horwitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

Original languageAmerican English
Article numbere02453-19
JournalAntimicrobial Agents and Chemotherapy
Volume64
Issue number4
DOIs
StatePublished - 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

Keywords

  • Antiretrovirals
  • Bariatric surgery
  • Obesity
  • Sleeve gastrectomy

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