Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Sarah Israel; Hila Elinav; Ram Elazary; Daniel Porat; Roni Gibori; Arik Dahan; Carmil Azran; Ehud Horwitz

doi:10.1128/AAC.02453-19

Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Sarah Israel^*
, Hila Elinav
, Ram Elazary
, Daniel Porat
, Roni Gibori
, Arik Dahan
, Carmil Azran
, Ehud Horwitz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

Original language	English
Article number	e02453-19
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02453-19
State	Published - 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antiretrovirals
Bariatric surgery
Obesity
Sleeve gastrectomy

Access to Document

10.1128/AAC.02453-19

Cite this

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title = "Case report of increased exposure to antiretrovirals following sleeve gastrectomy",

abstract = "Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased \textasciitilde{}12-fold. Several mechanistic explanations for these findings are discussed.",

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AU - Israel, Sarah

AU - Elinav, Hila

AU - Elazary, Ram

AU - Porat, Daniel

AU - Gibori, Roni

AU - Dahan, Arik

AU - Azran, Carmil

AU - Horwitz, Ehud

PY - 2020

Y1 - 2020

N2 - Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

AB - Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

KW - Antiretrovirals

KW - Bariatric surgery

KW - Obesity

KW - Sleeve gastrectomy

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JO - Antimicrobial Agents and Chemotherapy

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IS - 4

M1 - e02453-19

ER -

Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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