TY - JOUR
T1 - Catalytic monoclonal antibodies
T2 - tailor-made, enzyme-like catalysts for chemical reactions
AU - Green, Bernard S.
AU - Tawfik, Dan S.
PY - 1989/11
Y1 - 1989/11
N2 - During the past two years, monoclonal antibodies with enzyme-like catalytic properties have been successfully raised. They catalyse a variety of reactions (hydrolysis of esters, amides and carbonates; bimolecular reactions; cyclization reactions; elimination reactions; asymmetric synthesis) with rate enhancements of up to 6 × 106 fold and high specificity, including enantiomer specificity. Hybrid antibodies containing covalently-linked catalytic or probe groups have been prepared and antibody-mediated peptide hydrolysis catalysed by metal ion complexes has been reported. Catalytic monoclonal antibodies could have wide-ranging, exciting applications in biology, medicine, chemistry and biotechnology.
AB - During the past two years, monoclonal antibodies with enzyme-like catalytic properties have been successfully raised. They catalyse a variety of reactions (hydrolysis of esters, amides and carbonates; bimolecular reactions; cyclization reactions; elimination reactions; asymmetric synthesis) with rate enhancements of up to 6 × 106 fold and high specificity, including enantiomer specificity. Hybrid antibodies containing covalently-linked catalytic or probe groups have been prepared and antibody-mediated peptide hydrolysis catalysed by metal ion complexes has been reported. Catalytic monoclonal antibodies could have wide-ranging, exciting applications in biology, medicine, chemistry and biotechnology.
UR - http://www.scopus.com/inward/record.url?scp=0024764124&partnerID=8YFLogxK
U2 - 10.1016/0167-7799(89)90112-1
DO - 10.1016/0167-7799(89)90112-1
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AN - SCOPUS:0024764124
SN - 0167-7799
VL - 7
SP - 304
EP - 310
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 11
ER -