Abstract
Transfer hydrogenation reactions are of great interest to reduce diverse molecules under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines, etc. The reduction of benzene derivatives by transfer hydrogenation has never been described, which is likely due to the high energy barrier required to dearomatize these compounds. In this context, we have developed a catalytic transfer hydrogenation reaction for the reduction of benzene derivatives and heteroarenes to form complex 3-dimensional scaffolds bearing various functional groups at room temperature without needing compressed hydrogen gas.
Original language | American English |
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Pages (from-to) | 14090-14094 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 26 |
Issue number | 62 |
DOIs | |
State | Published - 6 Nov 2020 |
Externally published | Yes |
Bibliographical note
Funding Information:We thank the European Research Council (ERC Advanced Grant Agreement no. 788558), the Alexander von Humboldt Foundation (C.G.), the Alfried Krupp von Bohlen and Hallbach Foundation (A.H.) and the Hans‐Jensen‐Minerva Foundation (Z.N.) for generous financial support. The authors also thank Dr. Michael J. James for helpful discussions, Matthias Freitag, Martin Bühner (nanoAnalyticsGmbH) for SEM analysis and Dr. Klaus Bergander for NMR measurements. Open access funding enabled and organized by Projekt DEAL.
Funding Information:
We thank the European Research Council (ERC Advanced Grant Agreement no. 788558), the Alexander von Humboldt Foundation (C.G.), the Alfried Krupp von Bohlen and Hallbach Foundation (A.H.) and the Hans-Jensen-Minerva Foundation (Z.N.) for generous financial support. The authors also thank Dr. Michael J. James for helpful discussions, Matthias Freitag, Martin Bühner (nanoAnalyticsGmbH) for SEM analysis and Dr. Klaus Bergander for NMR measurements. Open access funding enabled and organized by Projekt DEAL.
Publisher Copyright:
© 2020 The Authors. Published by Wiley-VCH GmbH
Keywords
- arene reduction
- catalysis
- organic chemistry
- rhodium
- transfer hydrogenation