Catalytic Transfer Hydrogenation of Arenes and Heteroarenes

Coralie Gelis, Arne Heusler, Zackaria Nairoukh, Frank Glorius*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Transfer hydrogenation reactions are of great interest to reduce diverse molecules under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines, etc. The reduction of benzene derivatives by transfer hydrogenation has never been described, which is likely due to the high energy barrier required to dearomatize these compounds. In this context, we have developed a catalytic transfer hydrogenation reaction for the reduction of benzene derivatives and heteroarenes to form complex 3-dimensional scaffolds bearing various functional groups at room temperature without needing compressed hydrogen gas.

Original languageAmerican English
Pages (from-to)14090-14094
Number of pages5
JournalChemistry - A European Journal
Volume26
Issue number62
DOIs
StatePublished - 6 Nov 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Published by Wiley-VCH GmbH

Keywords

  • arene reduction
  • catalysis
  • organic chemistry
  • rhodium
  • transfer hydrogenation

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